Rageh Mahmoud A, Elrewiny Emad M, Kadah Ahmed S, Zakaria Hazem B, Abdelshakour Mohamed, Mohy Sara M, Mahmoud Waleed Ahmed, Suliman Ahmed A, Mohamed Ahmed Abdelkader
Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Department of Dermatology, Faculty of Medicine for Girls, Al-Azhar University, New Damietta, Egypt.
Arch Dermatol Res. 2025 Apr 1;317(1):663. doi: 10.1007/s00403-025-04112-2.
Atrophic acne scarring is a prevalent problem that has been treated with a variety of procedures, each with various degrees of success. For better results, combined regimens of treatment are recommended. Our aim was to compare the efficacy of topical insulin against topical platelet-rich plasma (PRP) as an adjunct treatment to fractional CO2 laser for atrophic acne scars. The study comprised 30 patients with atrophic acne scars. All patients underwent four sessions of fractional CO2 laser on both sides of the face at one-month intervals, followed by topical PRP treatment on one side of the face and topical insulin on the other. Two non-treating dermatologists used the Acne Scar Assessment Scale (ASAS) to assess the outcome. At their last follow-up appointment, patients were asked to assess their improvement on each side of the face in a percentage from 0 to 100%. Prior to treatment, there was no difference in the ASAS scores between the two sides of the face. One month after the last treatment session, ASAS scores improved significantly on both sides of the face. No significant difference (p = 0.794) between both sides were detected. Both techniques helped to improve atrophic acne scars and may have a synergistic outcome regarding efficacy and safety.
萎缩性痤疮瘢痕是一个普遍存在的问题，人们已经采用了多种方法对其进行治疗，每种方法的成功率各不相同。为了获得更好的效果，推荐联合治疗方案。我们的目的是比较外用胰岛素与外用富血小板血浆（PRP）作为非剥脱性二氧化碳激光治疗萎缩性痤疮瘢痕辅助治疗方法的疗效。该研究纳入了30例患有萎缩性痤疮瘢痕的患者。所有患者均接受了4次面部双侧非剥脱性二氧化碳激光治疗，每次间隔1个月，随后一侧面部接受外用PRP治疗，另一侧面部接受外用胰岛素治疗。两名非治疗皮肤科医生使用痤疮瘢痕评估量表（ASAS）评估治疗结果。在最后一次随访预约时，要求患者以0%至100%的百分比评估其面部两侧的改善情况。治疗前，面部两侧的ASAS评分无差异。在最后一次治疗疗程后1个月，面部两侧的ASAS评分均显著改善。两侧之间未检测到显著差异（p = 0.794）。两种技术均有助于改善萎缩性痤疮瘢痕，并且在疗效和安全性方面可能具有协同效果。
