Kobayashi Y, Fujii K, Kurokawa A, Kamiyama M, Miyazawa H
Department of Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Nephron. 1988;48(1):33-9. doi: 10.1159/000184865.
A 44-year-old man demonstrated proteinuria, microhematuria and renal dysfunction during the course of hyperthyroidism. Neither cryoglobulinemia nor paraproteinemia including light chains was found. No systemic signs suggestive of amyloidosis appeared. Histological findings showed a diffuse mesangial matrix increase with slight mesangial proliferation and diffuse granular depositions of IgG, IgA, C3, C4, Clq, kappa and lambda light chains. Ultrastructurally, microfibrils of about 20 nm in width were seen to be deposited diffusely in mesangial areas and in glomerular basement membranes. Congo red and thioflavin T staining were negative. These findings support the possible existence of a specific glomerular disease different from amyloidosis.
一名44岁男性在甲状腺功能亢进症病程中出现蛋白尿、镜下血尿和肾功能不全。未发现冷球蛋白血症或包括轻链在内的副蛋白血症。未出现提示淀粉样变性的全身症状。组织学检查结果显示弥漫性系膜基质增加，伴有轻微系膜增生，以及IgG、IgA、C3、C4、Clq、κ和λ轻链的弥漫性颗粒状沉积。超微结构上，可见宽度约20nm的微纤维弥漫性沉积于系膜区和肾小球基底膜。刚果红和硫黄素T染色均为阴性。这些发现支持可能存在一种不同于淀粉样变性的特定肾小球疾病。
