Martínez-Roig A, Torres-Rodríguez J M, Bartlett-Coma A
Department of Pediatrics, Hospital Nuestra Señora del Mar, Barcelona, Spain.
Pediatr Infect Dis J. 1988 Jan;7(1):37-40. doi: 10.1097/00006454-198801000-00009.
Ketoconazole and griseofulvin were compared in a double blind fashion in 47 children with dermatophytosis and positive fungal culture. After 6 weeks of therapy there was clinical and mycologic cure or improvement of the lesions in 92% of patients treated with ketoconazole (Group A) and in 76% of those given griseofulvin (Group B). A patient in Group A showed clinical deterioration of the lesions after 4 weeks of treatment, although modification of antifungal therapy was not necessary to achieve final healing. One ketoconazole-treated patient relapsed within 7 days after cessation of therapy. In Group B the antifungal agent was changed in five cases due to worsening or slow resolution of the lesions and persistence of positive cultures after 6 weeks of treatment. Both ketoconazole and griseofulvin were useful drugs for treatment of dermatophytoses in children.
酮康唑和灰黄霉素以双盲方式对47例皮肤癣菌病且真菌培养阳性的儿童进行了比较。治疗6周后，酮康唑治疗组（A组）92%的患者皮损实现临床和真菌学治愈或改善，灰黄霉素治疗组（B组）为76%。A组一名患者在治疗4周后皮损出现临床恶化，不过实现最终治愈无需调整抗真菌治疗。一名酮康唑治疗的患者在治疗停止后7天内复发。B组有5例因皮损恶化或消退缓慢以及治疗6周后真菌培养持续阳性而更换了抗真菌药物。酮康唑和灰黄霉素都是治疗儿童皮肤癣菌病的有效药物。
