Svejgaard E
Acta Derm Venereol. 1985;65(2):143-9.
In an open study 58 patients with chronic dermatophytosis mainly caused by Trichophyton rubrum and five patients with Tinea capitis were treated with ketoconazole. The indications were ineffectiveness of or side effects to griseofulvin. Response to treatment varied from 1 week in scalp infections to 11 weeks in toe-nail lesions. Dermatophytosis of hands and feet were cured in 25%, marked improvement observed in further 30%. Toe- and finger-nail infections were cured in 20% and 43%, respectively, and marked improvement seen in further 36% and 14%, respectively. All scalp infections were cured without relapse. Recurrence of infections before 6 months after treatment was seen in 55-60% of hand and foot lesions and 33-38% of finger and toe-nail infections. In a double-blind study 20 patients with onychomycosis caused by T. rubrum the efficacy of ketoconazole was compared to that of griseofulvin. Cure rates in the griseofulvin group were 25% for finger-nails and zero for toe-nails, while 50% and 57% experienced marked improvement. In the ketoconazole group, 25% of finger-nail infections were cured and 75% markedly improved, while the corresponding figures for toe-nails were 11% and 89%, respectively. Adverse reactions to ketoconazole were seen in 29 (46%) of the patients in the open study and in 2 (20%) in the double-blind study and comprised mainly minor complaints. Side effects caused discontinuation in 12 patients, in two of whom due to toxic hepatitis.
在一项开放性研究中，对58例主要由红色毛癣菌引起的慢性皮肤癣菌病患者和5例头癣患者使用酮康唑进行治疗。适应证为对灰黄霉素无效或出现副作用。治疗反应从头皮感染的1周到趾甲病变的11周不等。手足皮肤癣菌病25%治愈，另有30%有显著改善。趾甲和指甲感染的治愈率分别为20%和43%，另有36%和14%有显著改善。所有头皮感染均治愈且无复发。治疗后6个月内，手足病变感染复发率为55% - 60%，指甲和趾甲感染复发率为33% - 38%。在一项双盲研究中，对20例由红色毛癣菌引起的甲癣患者比较了酮康唑与灰黄霉素的疗效。灰黄霉素组指甲治愈率为25%，趾甲治愈率为零，另有50%和57%有显著改善。酮康唑组指甲感染治愈率为25%，另有75%有显著改善，趾甲相应治愈率分别为11%和89%。开放性研究中29例（46%）患者出现酮康唑不良反应，双盲研究中有2例（20%）出现不良反应，主要为轻微不适。副作用导致12例患者停药，其中2例因中毒性肝炎停药。
