CIRUS Centre for Sleep and Chronobiology - NHMRC Centre of Research Excellence, Woolcock Institute of Medical Research, University of Sydney, PO Box M77, Missenden Road, Sydney, NSW, 2050, Australia.
Sydney Nursing School, University of Sydney, Sydney, NSW, Australia.
Sleep Breath. 2021 Mar;25(1):347-354. doi: 10.1007/s11325-020-02066-5. Epub 2020 Aug 9.
Using quantitative EEG (qEEG) analysis, we investigated sleep EEG microstructure as correlates of neurobehavioural performance after 24 h of extended wakefulness in untreated OSA.
Eight male OSA patients underwent overnight polysomnography (PSG) at baseline followed by 40 h awake with repeated performance testing (psychomotor vigilance task [PVT] and AusEd driving simulator). EEG slowing during REM and spindle density during NREM sleep were calculated using power spectral analysis and a spindle detection algorithm at frontal and central electrode sites. Correlations between sleep EEG microstructure measures and performance after 24-h awake were assessed.
Greater EEG slowing during REM sleep was associated with slower PVT reaction times (rho = - 0.79, p = 0.02), more PVT lapses (rho = 0.87, p = 0.005) and more AusEd crashes (rho = 0.73, p = 0.04). Decreased spindle density in NREM sleep was also associated with slower PVT reaction times (rho = 0.89, p = 0.007). Traditional PSG measures of disease severity were not consistent correlates of neurobehavioural performance in OSA.
Sleep EEG microstructure measures recorded during routine PSG are associated with impaired vigilance in OSA patients after sleep deprivation.
Quantitative brain oscillatory (or EEG)-based measures of sleep may better reflect the deleterious effects of untreated OSA than traditional PSG metrics in at-risk individuals. Trial Registration ACTRN12606000066583.
通过定量脑电图 (qEEG) 分析，我们研究了未经治疗的阻塞性睡眠呼吸暂停 (OSA) 患者延长清醒时间 24 小时后睡眠 EEG 微观结构与神经行为表现的相关性。
8 名男性 OSA 患者在基线时进行了一夜的多导睡眠图 (PSG) 检查，然后在清醒状态下进行了 40 小时的重复性能测试（精神运动警觉任务 [PVT] 和 AusEd 驾驶模拟器）。使用功率谱分析和纺锤检测算法在前额和中央电极部位计算 REM 睡眠期间的 EEG 减慢和 NREM 睡眠期间的纺锤密度。评估睡眠 EEG 微观结构测量值与 24 小时清醒后表现之间的相关性。
REM 睡眠期间 EEG 减慢与 PVT 反应时间较慢相关（rho = -0.79，p = 0.02），PVT 失误较多（rho = 0.87，p = 0.005），AusEd 崩溃较多（rho = 0.73，p = 0.04）。NREM 睡眠中纺锤密度降低也与 PVT 反应时间较慢相关（rho = 0.89，p = 0.007）。疾病严重程度的传统 PSG 测量值与 OSA 患者睡眠剥夺后的神经行为表现不一致。
在常规 PSG 期间记录的睡眠 EEG 微观结构测量值与 OSA 患者睡眠剥夺后的警觉性受损有关。
与传统 PSG 指标相比，基于脑振荡（或 EEG）的睡眠定量测量值可能更好地反映未经治疗的 OSA 在高危人群中的有害影响。
ACTRN12606000066583。
