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具有抗HIV活性的天然产物的分离、生物活性及合成。 （注：原句“from with anti-HIV activities”表述有误，推测正确表述应为“with anti-HIV activities”，翻译据此调整。）

The isolation, bioactivity, and synthesis of natural products from with anti-HIV activities.

作者信息

Yan Jia-Lei, Nan Huiru, Fang Xiaoyu, Long Xiong-En, Jiang Yu, Liu Junyang

机构信息

School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.

出版信息

Front Pharmacol. 2024 Dec 9;15:1477878. doi: 10.3389/fphar.2024.1477878. eCollection 2024.

DOI:10.3389/fphar.2024.1477878
PMID:39717550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663674/
Abstract

Natural products isolated from have attracted considerable attention from the chemical community due to their unique structures and promising anti-HIV activities. Recent progresses in the isolation and bioactivity studies for these natural molecules were summarized comprehensively. From the 23 previously uncharacterized compounds isolated from the plant , litseaverticillol B demonstrated the most potent anti-HIV activity , with IC ranging from 2 to 3 μg/mL. Meanwhile, litseaverticillol E displayed the highest selectivity index (SI = 3.1), indicating a favorable balance between antiviral potency and cellular toxicity. The plausible biosynthetic pathways and the total synthetic approaches for the representative members (litseaverticillols) were introduced in detail.

摘要

从[植物名称未给出]中分离出的天然产物因其独特的结构和有前景的抗HIV活性而引起了化学界的广泛关注。全面总结了这些天然分子在分离和生物活性研究方面的最新进展。从该植物中分离出的23种先前未表征的化合物中，轮叶木姜子醇B表现出最强的抗HIV活性，IC50范围为2至3μg/mL。同时，轮叶木姜子醇E显示出最高的选择性指数（SI = 3.1），表明在抗病毒效力和细胞毒性之间具有良好的平衡。详细介绍了代表性成员（轮叶木姜子醇）合理的生物合成途径和全合成方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/11663674/650032893fb8/fphar-15-1477878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/11663674/650032893fb8/fphar-15-1477878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/11663674/650032893fb8/fphar-15-1477878-g001.jpg

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