用于第二代磁共振兼容单光子发射计算机断层扫描的原型倒置复眼伽马相机的系统建模与评估
System Modeling and Evaluation of a Prototype Inverted-Compound Eye Gamma Camera for the Second Generation MR Compatible SPECT.
作者信息
Lai Xiaochun, Zannoni Elena M, George Jonathan, Meng Ling-Jian
机构信息
Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign.
Department of Bioengineering, University of Illinois at Urbana-Champaign.
出版信息
Nucl Instrum Methods Phys Res A. 2020 Feb 21;954. doi: 10.1016/j.nima.2019.04.001. Epub 2019 Apr 17.
We have reported the design of the MRC-SPECT-II system based on the inverted-compound-eye (ICE) gamma camera to offer a > 1% detection efficiency while maintaining a sub-500 m imaging resolution [1]. One of the key challenges of using the ICE camera for SPECT imaging is whether one could develop an accurate point response function (PRF), given its complex aperture design and low fractionation accuracy of 3D printing. In this work, we will discuss (I) a combined experimental and analytical approach for deriving the precise PRF, and (II) an experimental imaging study to demonstrate the feasibility of using the ICE-camera for acquiring high-quality SPECT images with a sub-500 m resolution. These studies would help to overcome one of the major hurdles for implement ICE-cameras for practical SPECT imaging.
我们已经报道了基于倒置复眼（ICE）γ相机的MRC-SPECT-II系统的设计，该系统在保持亚500微米成像分辨率的同时，检测效率大于1%[1]。将ICE相机用于SPECT成像的关键挑战之一是，鉴于其复杂的孔径设计和3D打印的低分馏精度，能否开发出精确的点响应函数（PRF）。在这项工作中，我们将讨论：（I）一种用于推导精确PRF的实验与分析相结合的方法；（II）一项实验成像研究，以证明使用ICE相机获取分辨率低于500微米的高质量SPECT图像的可行性。这些研究将有助于克服将ICE相机用于实际SPECT成像的一个主要障碍。
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