基于倒置复眼γ相机设计的第二代磁共振兼容 SPECT 系统的仿真研究。
Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design.
机构信息
Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign, 104 S Wright St, Urbana, IL 61801, United States of America.
出版信息
Phys Med Biol. 2018 Feb 12;63(4):045008. doi: 10.1088/1361-6560/aaa4fb.
In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diameter of 6 cm. This system provides a FOV of 1 cm diameter and a peak geometrical efficiency of approximately 1.3% (the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining a sub-500 μm spatial resolution. Compared to the first-generation MRC-SPECT system (MRC-SPECT-I) (Cai 2014 Nucl. Instrum. Methods Phys. Res. A 734 147-51) developed in our lab, the MRC-SPECT-II system offers a similar resolution with dramatically improved sensitivity and greatly reduced physical dimension. The latter should allow the system to be placed inside most clinical and pre-clinical MRI scanners for high-performance simultaneous MRI and SPECT imaging.
本文介绍了第二代基于倒置复眼（ICE）γ相机概念的磁共振兼容单光子发射计算机断层成像系统（MRC-SPECT-II）的仿真研究。MRC-SPECT-II 系统由总共 1536 个独立的微针孔相机元件（MCE）组成，分布在一个内径为 6cm 的圆环上。该系统提供了 1cm 直径的视场和大约 1.3%的峰值几何效率（现代临床前 SPECT 仪器中常见的水平为 0.1%-0.01%），同时保持了低于 500μm 的空间分辨率。与我们实验室开发的第一代 MRC-SPECT 系统（MRC-SPECT-I）（Cai 2014 Nucl. Instrum. Methods Phys. Res. A 734 147-51）相比，MRC-SPECT-II 系统具有类似的分辨率，但灵敏度显著提高，物理尺寸大大减小。后者应该允许系统被放置在大多数临床和临床前磁共振成像扫描仪内部，以实现高性能的同时磁共振成像和单光子发射计算机断层成像。
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