Hutton Brian F, Occhipinti Michele, Kuehne Andre, Máthé Domokos, Kovács Noémi, Waiczies Helmar, Erlandsson Kjell, Salvado Debora, Carminati Marco, Montagnani Giovanni L, Short Susan C, Ottobrini Luisa, van Mullekom Pieter, Piemonte Claudio, Bukki Tamas, Nyitrai Zoltan, Papp Zoltan, Nagy Kalman, Niendorf Thoralf, de Francesco Irene, Fiorini Carlo
1 Institute of Nuclear Medicine, University College London (UCL), London, UK.
2 Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano and Instituto Nacionale di Fisica Nucleare (INFN), Milan, Italy.
Br J Radiol. 2018 Jan;91(1081):20160690. doi: 10.1259/bjr.20160690. Epub 2017 Mar 7.
There is increasing clinical use of combined positron emission tomography and MRI, but to date there has been no clinical system developed capable of simultaneous single-photon emission computed tomography (SPECT) and MRI. There has been development of preclinical systems, but there are several challenges faced by researchers who are developing a clinical prototype including the need for the system to be compact and stationary with MRI-compatible components. The limited work in this area is described with specific reference to the Integrated SPECT/MRI for Enhanced stratification in Radio-chemo Therapy (INSERT) project, which is at an advanced stage of developing a clinical prototype. Issues of SPECT/MRI compatibility are outlined and the clinical appeal of such a system is discussed, especially in the management of brain tumour treatment.
正电子发射断层扫描与磁共振成像相结合的临床应用日益增多，但迄今为止，尚未开发出能够同时进行单光子发射计算机断层扫描（SPECT）和磁共振成像的临床系统。虽然已经有了临床前系统，但开发临床原型的研究人员面临着几个挑战，包括系统需要紧凑且固定，以及部件要与磁共振成像兼容。本文结合用于放化疗强化分层的集成SPECT/磁共振成像（INSERT）项目，对该领域有限的研究工作进行了描述，该项目正处于临床原型开发的高级阶段。文中概述了SPECT/磁共振成像兼容性问题，并讨论了这种系统的临床吸引力，特别是在脑肿瘤治疗管理方面。
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