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蜂王浆对牙周病原菌抗菌活性的评估与比较：一项整体性治疗研究

Evaluation and comparison of the antimicrobial activity of royal jelly - A holistic healer against periodontopathic bacteria: An study.

作者信息

Khosla Anjali, Gupta Swyeta Jain, Jain Anshi, Shetty Devi Charan, Sharma Nikhil

机构信息

Department of Periodontology, I T S Dental College, Ghaziabad, Uttar Pradesh, India.

Department of Oral Pathology and Microbiology, I T S Dental College, Ghaziabad, Uttar Pradesh, India.

出版信息

J Indian Soc Periodontol. 2020 May-Jun;24(3):221-226. doi: 10.4103/jisp.jisp_486_19. Epub 2020 May 4.

DOI:10.4103/jisp.jisp_486_19
PMID:32773971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7307477/
Abstract

CONTEXT

RJ is a natural bee product and is known to have remarkable health benefits. The objective was to evaluate its antimicrobial potential against periodontopathic bacteria and compare the same with chlorhexidine.

AIMS

The aim was to evaluate and compare the antimicrobial activity of royal jelly (RJ) with chlorhexidine against the periodontopathic bacteria (aerobic and anaerobic) in subgingival plaque.

MATERIALS AND METHODS

Subgingival plaque samples of 15 chronic periodontitis patients were taken, and clinical parameters were evaluated. Inhibitory effect of RJ and chlorhexidine was investigated "" on the growth of aerobic and anaerobic bacteria by colony count, minimum inhibitory concentration, and minimum bactericidal concentration (MBC) by the method of serial broth dilution.

STATISTICAL ANALYSIS USED

ANOVA statistical analysis was used in this study.

RESULTS

Subgingival anaerobic bacteria predominate (colony-forming unit). Chlorhexidine is more sensitive in inhibiting aerobic and anaerobic bacteria (at concentration 50 μg/100 μl). A higher concentration of RJ is required to have an inhibitory effect. MBC of chlorhexidine shows no growth on blood agar plates, whereas minimum bacterial growth is seen around the RJ.

CONCLUSIONS

Chlorhexidine (gold standard) has a higher inhibitory effect in the case of chronic periodontitis; however, RJ can also be used as an alternative but at higher concentration and lesser dilution. Evaluation of the quality, quantity and the biological activity of RJ is a necessity and must be done before its "in vivo" application.

摘要

背景

蜂王浆是一种天然蜂产品，已知具有显著的健康益处。目的是评估其对牙周病原菌的抗菌潜力，并与氯己定进行比较。

目的

评估并比较蜂王浆（RJ）和氯己定对龈下菌斑中牙周病原菌（需氧菌和厌氧菌）的抗菌活性。

材料与方法

采集15例慢性牙周炎患者的龈下菌斑样本，并评估临床参数。采用肉汤稀释法，通过菌落计数、最低抑菌浓度和最低杀菌浓度（MBC）研究RJ和氯己定对需定对需氧菌和厌氧菌生长的抑制作用。

所用统计分析方法

本研究采用方差分析。

结果

龈下厌氧菌占主导（菌落形成单位）。氯己定在抑制需氧菌和厌氧菌方面更敏感（浓度为50μg/100μl时）。需要更高浓度的RJ才能产生抑制作用。氯己定的MBC在血琼脂平板上无生长，而在RJ周围可见最小细菌生长。

结论

在慢性牙周炎病例中，氯己定（金标准）具有更高的抑制作用；然而，RJ也可作为替代品使用，但需要更高的浓度和更低的稀释度。在“体内”应用RJ之前，必须对其质量、数量和生物活性进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/f78b90cca8ab/JISP-24-221-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/dc57b399d156/JISP-24-221-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/c715c1161f15/JISP-24-221-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/1668cd3f6b76/JISP-24-221-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/d255206959cf/JISP-24-221-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/273812c1f496/JISP-24-221-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/f78b90cca8ab/JISP-24-221-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/dc57b399d156/JISP-24-221-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/c715c1161f15/JISP-24-221-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/1668cd3f6b76/JISP-24-221-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/d255206959cf/JISP-24-221-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/273812c1f496/JISP-24-221-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4382/7307477/f78b90cca8ab/JISP-24-221-g006.jpg

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