Kumar Manoj, Prakash Suraj, Lorenzo José M, Chandran Deepak, Dhumal Sangram, Dey Abhijit, Senapathy Marisennayya, Rais Nadeem, Singh Surinder, Kalkreuter Phillip, Damale Rahul D, Natta Suman, Vishvanathan Marthandan, Sathyaseelan Sangeetha Kizhakkumkara, Rajalingam Sureshkumar, Viswanathan Sabareeshwari, Murugesan Yasodha, Muthukumar Muthamilselvan, Jayaraman Aravind, Kalirajan Murugasridevi, Selim Samy, Amarowicz Ryszard, Mekhemar Mohamed
Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India.
School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management 3 Sciences, Solan 173229, India.
Antioxidants (Basel). 2022 Apr 22;11(5):823. doi: 10.3390/antiox11050823.
Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20-50% of the global population. In recent years, more preference has been given to natural therapies compared to synthetic drugs in the treatment of periodontal disease, and several oral care products, such as toothpaste, mouthwash, and dentifrices, have been developed comprising honeybee products, such as propolis, honey, royal jelly, and purified bee venom. In this study, we systematically reviewed the literature on the treatment of periodontitis using honeybee products. A literature search was performed using various databases, including PubMed, Web of Science, ScienceDirect, Scopus, clinicaltrials.gov, and Google Scholar. A total of 31 studies were reviewed using eligibility criteria published between January 2016 and December 2021. In vitro, in vivo, and clinical studies (randomized clinical trials) were included. Based on the results of these studies, honeybee products, such as propolis and purified bee venom, were concluded to be effective and safe for use in the treatment of periodontitis mainly due to their antimicrobial and anti-inflammatory activities. However, to obtain reliable results from randomized clinical trials assessing the effectiveness of honeybee products in periodontal treatment with long-term follow-up, a broader sample size and assessment of various clinical parameters are needed.
牙周疾病主要由牙齿周围牙龈和骨骼的炎症或口腔微生物群失调引起，《2019年全球疾病负担研究》报告称，牙周疾病影响全球20%至50%的人口。近年来，与合成药物相比，天然疗法在牙周疾病治疗中更受青睐，并且已经开发了几种口腔护理产品，如牙膏、漱口水和洁齿剂，它们含有蜂胶、蜂蜜、蜂王浆和纯化蜂毒等蜂产品。在本研究中，我们系统回顾了关于使用蜂产品治疗牙周炎的文献。使用包括PubMed、科学网、ScienceDirect、Scopus、clinicaltrials.gov和谷歌学术在内的各种数据库进行文献检索。根据2016年1月至2021年12月发表的纳入标准，共审查了31项研究。纳入了体外、体内和临床研究（随机临床试验）。基于这些研究的结果，蜂胶和纯化蜂毒等蜂产品主要因其抗菌和抗炎活性而被认为在治疗牙周炎方面有效且安全。然而，为了从评估蜂产品在牙周治疗中的有效性并进行长期随访的随机临床试验中获得可靠结果，需要更大的样本量和对各种临床参数的评估。
