Lammie P J, Leiva L E, Ruff A J, Eberhard M L, Lowrie R C, Katz S P
Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.
Am J Trop Med Hyg. 1988 Jan;38(1):125-9. doi: 10.4269/ajtmh.1988.38.125.
Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
感染淋巴丝虫（班氏吴策线虫和马来布鲁线虫）的患者，其体外细胞对丝虫抗原的反应性受到抑制。在海地对班氏丝虫病的研究中，相当数量的微丝蚴血症患者可被归类为对丝虫抗原的“反应者”。通过体外细胞增殖试验检测发现，74名未经治疗的微丝蚴血症患者中有37名患者的细胞对彭亨丝虫抗原产生反应（刺激率大于2）。反应者与无反应者相比，平均彭亨丝虫反应性存在显著差异（15,822对4,538 cpm，P小于0.001），但在年龄、微丝蚴血症、结核菌素纯蛋白衍生物（PPD）或植物血凝素（PHA）反应性以及彭亨丝虫特异性抗体水平方面无显著差异。在蛋白质印迹法检测特定抗原的识别方面，这些组之间可能存在细微差异。
