Suda Mika, Yoshikawa Yuji, Terauchi Gaku, Matsumoto Soiti, Shoji Takuhei, Shinoda Kei, Mizota Atsushi, Kobayashi Yoshiharu
Department of Orthoptics, Teikyo University Faculty of Medical Technology, Tokyo, Japan.
Department of Ophthalmology, Saitama Medical University, Saitama, Japan.
Biomed Hub. 2020 Jun 12;5(2):79-86. doi: 10.1159/000507501. eCollection 2020 May-Aug.
The aim of this study was to evaluate the foveal avascular zone (FAZ) of healthy subjects and examine the magnification effect.
A total of 33 healthy volunteers were enrolled and all subjects were eligible for analysis. Optical coherence tomography angiography (OCTA) examination scanned 3 × 3 mm of the macular area. The FAZ area was measured on the superficial OCTA en face image with and without correction by axial length. The relationship between changes in the FAZ area after correction with the axial length was examined.
The mean age was 21.9 ± 0.6 years. The mean axial length was 24.87 ± 1.17 mm and mean spherical equivalent (SE) value was -3.64 ± 2.83 diopters (D). The FAZ area was 0.26 ± 0.10 mm before the axial length correction and 0.27 ± 0.10 mm after the correction. In the eyes that had an axial length longer than or equal to 26 mm or SE less than or equal to -6 D, the FAZ area after correction was significantly larger than that before correction ( < 0.01). The change of FAZ area after correction with axial length was significantly correlated with the axial length ( = 0.88, < 0.01) or SE value ( = 0.55, < 0.01).
FAZ areas were comparable to previous reports. In high myopic cases, the magnification effect needs to be considered when evaluating the FAZ area.
本研究旨在评估健康受试者的黄斑无血管区（FAZ）并研究放大效应。
共纳入33名健康志愿者，所有受试者均符合分析条件。光学相干断层扫描血管造影（OCTA）检查对黄斑区3×3mm区域进行扫描。在有无轴向长度校正的情况下，在OCTA表面正面图像上测量FAZ面积。研究校正轴向长度后FAZ面积变化之间的关系。
平均年龄为21.9±0.6岁。平均轴向长度为24.87±1.17mm，平均等效球镜度（SE）值为-3.64±2.83屈光度（D）。轴向长度校正前FAZ面积为0.26±0.10mm，校正后为0.27±0.10mm。在轴向长度大于或等于26mm或SE小于或等于-6D的眼中，校正后的FAZ面积显著大于校正前（<0.01）。校正轴向长度后FAZ面积的变化与轴向长度（=0.88，<0.01）或SE值（=0.55，<0.01）显著相关。
FAZ面积与先前报道相当。在高度近视病例中，评估FAZ面积时需要考虑放大效应。
