Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan, China.
Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
J Int Med Res. 2021 May;49(5):3000605211014994. doi: 10.1177/03000605211014994.
To evaluate the foveal avascular zone (FAZ) area in healthy volunteers using optical coherence tomography angiography (OCTA) and identify factors that influence the FAZ.
This single-center cross-sectional study included 526 eyes of 263 healthy volunteers who underwent macular scanning by Zeiss OCTA. A linear mixed model was used to investigate the effects of systemic factors (age, sex, blood pressure, height, and weight) and ocular factors (intraocular pressure, biometric parameters, and central macular thickness) on FAZ.
In total, 520 eyes of 262 healthy volunteers were included in the analysis. The mean volunteer age was 38.59 ± 22.03 years (range, 5-84 years); 124 volunteers were male (47.33%) and 138 volunteers were female (52.67%). The mean FAZ area was 0.30 ± 0.03 mm (95% confidence interval [CI], 0.29-0.31 mm). Univariate analysis showed that FAZ area was associated with age (β = 0.0011), anterior chamber depth (β = -0.0513), and axial length (β = -0.0202). Multivariate analysis showed that FAZ area was negatively correlated with axial length (β = -0.0181).
The mean FAZ area in healthy volunteers, measured using Zeiss OCTA, was 0.30 ± 0.03 mm. Furthermore, FAZ area was negatively associated with axial length; this relationship should be considered in clinical practice.
使用光相干断层扫描血管造影术（OCTA）评估健康志愿者的中心凹无血管区（FAZ）面积，并确定影响 FAZ 的因素。
这项单中心横断面研究纳入了 263 名健康志愿者的 526 只眼，这些志愿者均接受了蔡司 OCTA 的黄斑扫描。采用线性混合模型来研究系统性因素（年龄、性别、血压、身高和体重）和眼部因素（眼压、生物测量参数和中心黄斑厚度）对 FAZ 的影响。
共有 262 名健康志愿者的 520 只眼纳入了分析。志愿者的平均年龄为 38.59±22.03 岁（范围：5-84 岁）；124 名志愿者为男性（47.33%），138 名志愿者为女性（52.67%）。FAZ 面积的平均值为 0.30±0.03 mm（95%置信区间 [CI]，0.29-0.31 mm）。单变量分析显示，FAZ 面积与年龄（β=0.0011）、前房深度（β=-0.0513）和眼轴长度（β=-0.0202）有关。多变量分析显示，FAZ 面积与眼轴长度呈负相关（β=-0.0181）。
使用蔡司 OCTA 测量，健康志愿者的平均 FAZ 面积为 0.30±0.03 mm。此外，FAZ 面积与眼轴长度呈负相关；在临床实践中应考虑到这种关系。
