Shen Yun, Si Yiming, Lu Jingyi, Ma Xiaojing, Zhang Lei, Mo Yifei, Lu Wei, Zhu Wei, Bao Yuqian, Hu Gang, Zhou Jian
Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 200233.
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA 70806.
J Diabetes Res. 2020 Jul 21;2020:4243053. doi: 10.1155/2020/4243053. eCollection 2020.
The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes.
Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was assessed using arginine stimulation test. Decreased -cell function was defined as ACPR < 2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased -cell function.
Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased -cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) ( = 0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71).
We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with -cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings.
本研究旨在探讨2型糖尿病患者中1,5 - 脱水葡萄糖醇与精氨酸急性C肽反应（ACPR）之间的关联。
从上海第六人民医院内分泌代谢科招募2型糖尿病患者。使用精氨酸刺激试验评估ACPR。β细胞功能减退定义为ACPR < 2.1。采用多变量逻辑回归模型来证明1,5 - 脱水葡萄糖醇与β细胞功能减退之间的关联。
最终，623例2型糖尿病患者纳入分析。1,5 - 脱水葡萄糖醇四分位数分组中β细胞功能减退的多变量调整比值比分别为1.00、0.47（95%置信区间（CI）0.23 - 0.99）、0.41（95%CI 0.20 - 0.84）和0.27（95%CI 0.13 - 0.57）（P = 0.042）。当1,5 - 脱水葡萄糖醇对数转换后作为连续变量时，相应的比值比为0.40（95%CI 0.23 - 0.71）。
我们证明了1,5 - 脱水葡萄糖醇与ACPR之间存在剂量反应线性关联。1,5 - 脱水葡萄糖醇可能与β细胞功能相关。有必要进行更大样本量和前瞻性研究设计的进一步分析以验证我们的发现。
