Thiruvengadam R, Hench V, Melton L J, DiMagno E P
Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905.
Arch Intern Med. 1988 Feb;148(2):405-7.
To estimate the risk of esophageal, gallbladder, small-bowel, and colon cancers after gastric surgery for benign disease, all 337 residents of Olmsted County, Minnesota, who had surgical treatment of benign peptic ulcer disease during the years 1935 through 1959, were followed up. Patients were followed up for 6552 person-years of observation. No esophageal cancers developed (0.8 were expected). Members of the cohort developed one small-bowel malignant neoplasm (0.2 were expected), two gallbladder cancers (1.1 was expected), and four colon cancers (11.2 were expected), but these figures do not reflect a significant increase in the risk of these malignant neoplasms. In particular, the relative risk of developing colon cancer was only 0.4 when this analysis had 88% power to detect a relative risk of two or more. When the present investigation and two previous studies of this cohort were taken together, there was no strong evidence for an increased risk of any gastrointestinal cancer following gastric surgery.
为评估良性疾病胃手术后发生食管癌、胆囊癌、小肠癌和结肠癌的风险，对明尼苏达州奥尔姆斯特德县1935年至1959年间接受良性消化性溃疡疾病手术治疗的所有337名居民进行了随访。对患者进行了6552人年的观察随访。未发生食管癌（预期0.8例）。该队列成员发生了1例小肠恶性肿瘤（预期0.2例）、2例胆囊癌（预期1.1例）和4例结肠癌（预期11.2例），但这些数字并未反映出这些恶性肿瘤风险的显著增加。特别是，当该分析有88%的把握度检测到相对风险为2或更高时，发生结肠癌的相对风险仅为0.4。当将本调查与此前对该队列的两项研究结合起来时，没有强有力的证据表明胃手术后任何胃肠道癌症的风险增加。
