Department of Medicine and Surgery, Università degli Studi di Milano Bicocca, Milan, Italy.
Department of Medicine and Rehabilitation, Policlinico di Monza, Via Modigliani 10, 20900, Monza, MB, Italy.
J Endocrinol Invest. 2021 Apr;44(4):843-850. doi: 10.1007/s40618-020-01382-7. Epub 2020 Aug 10.
The purpose of this study was to evaluate the impact of pre-existing diabetes on in-hospital mortality in patients admitted for Coronavirus Disease 2019 (COVID-19).
This is a single center, retrospective study conducted at Policlinico di Monza hospital, located in the Lombardy region, Northern Italy. We reviewed medical records of 373 consecutive adult patients who were hospitalized with COVID-19 between February 22 and May 15, 2020. Data were collected on diabetes status, comorbid conditions and laboratory findings. Multivariable logistic regression was performed to evaluate the effect of diabetes on in-hospital mortality after adjustment for potential confounding variables.
Mean age of the patients was 72 ± 14 years (range 17-98), 244 (65.4%) were male and 69 (18.5%) had diabetes. The most common comorbid conditions were hypertension (237 [64.8%]), cardiovascular disease (140 [37.7%]) and malignant neoplasms (50 [13.6%]). In-hospital death occurred in 142 (38.0%) patients. In the multivariable model older age (Relative Risk [RR] 1.06 [1.04-1. 09] per year), diabetes (RR 1.56 [1.05-2.02]), chronic obstructive pulmonary disease (RR 1.82 [1.13-2.35]), higher values of lactic dehydrogenase and C-reactive protein were independently associated with in-hospital mortality.
In this retrospective single-center study, diabetes was independently associated with a higher in-hospital mortality. More intensive surveillance of patients with this condition is to be warranted.
本研究旨在评估患有 2019 年冠状病毒病（COVID-19）的患者中预先存在的糖尿病对住院死亡率的影响。
这是一项在意大利北部伦巴第大区蒙扎综合医院进行的单中心回顾性研究。我们回顾了 2020 年 2 月 22 日至 5 月 15 日期间因 COVID-19 住院的 373 例连续成年患者的病历。收集了糖尿病状态、合并症和实验室检查结果的数据。多变量逻辑回归用于评估在调整潜在混杂因素后，糖尿病对住院死亡率的影响。
患者的平均年龄为 72±14 岁（范围 17-98），244 例（65.4%）为男性，69 例（18.5%）患有糖尿病。最常见的合并症是高血压（237 例[64.8%]）、心血管疾病（140 例[37.7%]）和恶性肿瘤（50 例[13.6%]）。住院期间有 142 例（38.0%）患者死亡。在多变量模型中，年龄较大（每增加 1 岁，相对风险[RR]为 1.06[1.04-1.09]）、糖尿病（RR 1.56[1.05-2.02]）、慢性阻塞性肺疾病（RR 1.82[1.13-2.35]）、乳酸脱氢酶和 C 反应蛋白值较高与住院死亡率独立相关。
在这项回顾性单中心研究中，糖尿病与较高的住院死亡率独立相关。需要对患有这种疾病的患者进行更密切的监测。
