编码尿卟啉原III合酶的大肠杆菌hemD基因的核苷酸序列及hem操纵子的初步证据。
Nucleotide sequence for the hemD gene of Escherichia coli encoding uroporphyrinogen III synthase and initial evidence for a hem operon.
作者信息
Jordan P M, Mgbeje B I, Thomas S D, Alwan A F
机构信息
Department of Biochemistry, University of Southampton, U.K.
出版信息
Biochem J. 1988 Jan 15;249(2):613-6. doi: 10.1042/bj2490613.
Abstract
- The hemD gene, encoding uroporphyrinogen III synthase, has been located adjacent to the hemC gene at 85 min on the Escherichia coli chromosome. 2. The entire nucleotide sequence (741 base pairs) of the hemD gene is reported. 3. E. coli strains harbouring plasmics containing the hemD gene produce greatly elevated levels of uroporphyrinogen III synthase. 4. Purified uroporphyrinogen III synthase, isolated from the hemD-containing strain ST1046, has an Mr of 29,000, in close agreement with that predicted from the nucleotide sequence. 5. The existence of a hem operon is suggested.
摘要
- 编码尿卟啉原III合酶的hemD基因位于大肠杆菌染色体85分钟处，与hemC基因相邻。2. 报道了hemD基因的完整核苷酸序列（741个碱基对）。3. 携带含有hemD基因质粒的大肠杆菌菌株产生的尿卟啉原III合酶水平大幅升高。4. 从含有hemD的菌株ST1046中分离出的纯化尿卟啉原III合酶的相对分子质量为29000，与从核苷酸序列预测的结果非常一致。5. 提示存在一个hem操纵子。
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