Zhang Li, Yan Ruonan, Wu Zufang
Department of Physical Education, China University of Mining and Technology, Beijing, P.R. China.
Department of Food Science and Engineering, Ningbo University, Ningbo, P.R. China.
J Food Biochem. 2020 Oct;44(10):e13430. doi: 10.1111/jfbc.13430. Epub 2020 Aug 10.
The present study investigated the regulatory mechanism of green tea polyphenols (GTP) on the circadian rhythm of gut flora. The administration of GTP mitigated the variations in the serum and liver level of constant dark (CD)-induced circadian rhythm disorder mouse model. For the gut microbial population, GTP promoted the relative abundance of Bacteroidetes while inhibited Firmicutes. Furthermore, KEGG pathways of biosynthesis of amino acids, two-component system and ATP-binding cassette translocators enriched the most differentially expressed genes after GTP interference. It indicated GTP may prevent CD-induced circadian rhythm disorder, which has an enormous potential to be utilized as prebiotic-like ingredients in food industry. PRACTICAL APPLICATIONS: The findings underscore the capacity of GTP to modulate circadian rhythm by modulating the structure and functional characteristics of host gut microbiota and influencing metabolism, conducing to the melioration of human microecology. The prebiotic function of GTP indicated it can be used to prevent metabolic disturbance related to circadian rhythm disorder.
本研究探讨了绿茶多酚（GTP）对肠道菌群昼夜节律的调节机制。给予GTP可减轻持续黑暗（CD）诱导的昼夜节律紊乱小鼠模型血清和肝脏水平的变化。对于肠道微生物群，GTP促进了拟杆菌门的相对丰度，同时抑制了厚壁菌门。此外，氨基酸生物合成、双组分系统和ATP结合盒转运体的KEGG通路在GTP干扰后富集了最多的差异表达基因。这表明GTP可能预防CD诱导的昼夜节律紊乱，在食品工业中作为益生元样成分具有巨大的应用潜力。实际应用：研究结果强调了GTP通过调节宿主肠道微生物群的结构和功能特征以及影响新陈代谢来调节昼夜节律的能力，有助于改善人类微生态。GTP的益生元功能表明它可用于预防与昼夜节律紊乱相关的代谢紊乱。
