Department of Food Science and Engineering , Ningbo University , Ningbo 315211 , P.R. China.
Department of Food Science , Rutgers University , New Brunswick , New Jersey 08901 , United States.
J Agric Food Chem. 2019 Aug 14;67(32):8847-8854. doi: 10.1021/acs.jafc.9b03000. Epub 2019 Aug 1.
Microbiome has been revealed as a key element involved in maintaining the circadian rhythms. Oolong tea polyphenols (OTP) has been shown to have potential prebiotic activity. Therefore, this study focused on the regulation mechanisms of OTP on host circadian rhythms. After 8 weeks of OTP administration, a large expansion in the relative abundance of with a decrease in was observed, which reflected the positive modulatory effect of OTP on gut flora. In addition, Kyoto Encyclopedia of Genes and Genomes pathways of ATP-binding cassette transporters, two-component system, and the biosynthesis of amino acids enriched the most differentially expressed genes after OTP treatment. Of the differentially expressed proteins identified, most were related to metabolism, genetic information processing, and environmental information processing. It underscores the ability of OTP to regulate circadian rhythm by enhancing beneficial intestinal microbiota and affecting metabolic pathways, contributing to the improvement of host microecology.
微生物组已被揭示为参与维持昼夜节律的关键因素。乌龙茶多酚（OTP）已显示出具有潜在的益生元活性。因此，本研究专注于 OTP 对宿主昼夜节律的调节机制。经过 8 周的 OTP 给药后，观察到相对丰度的 大量增加，而 的相对丰度减少，这反映了 OTP 对肠道菌群的积极调节作用。此外，京都基因与基因组百科全书通路中的 ATP 结合盒转运蛋白、双组分系统和氨基酸生物合成在 OTP 处理后富集了最多的差异表达基因。在鉴定出的差异表达蛋白中，大多数与代谢、遗传信息处理和环境信息处理有关。这强调了 OTP 通过增强有益肠道微生物群和影响代谢途径来调节昼夜节律的能力，有助于改善宿主微生态。
