Division of Pediatric Nephrology, Cohen Children's Medical Center of New York, New Hyde Park, New York, USA.
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA.
Pediatr Obes. 2021 Feb;16(2):e12706. doi: 10.1111/ijpo.12706. Epub 2020 Aug 10.
The Children's Dietary Inflammatory Index (C-DII) has been validated to characterize the inflammatory potential of an individual child's diet.
To determine the association between C-DII and markers of cardiometabolic risk (adiposity, blood pressure [BP], lipids, albuminuria, glomerular hyperfiltration) in adolescents.
Participants aged 12-18 enrolled in NHANES from 2005 to 2014 who completed a 24-hour dietary recall were included in this cross-sectional study. Regression models adjusted for age, sex, race and height examined associations of C-DII quartiles stratified by weight status.
Among adolescents (mean age 15 years), the average C-DII score was 0.86 (SE 0.04). When comparing C-DII quartile 4 (most pro-inflammatory) to quartile 1 (most anti-inflammatory), there was a positive association with albuminuria (OR 1.44, 95% CI 1.02, 2.03). After stratifying by weight status, C-DII quartile was found to be significantly associated with albuminuria (OR 4.27, 95% CI 1.83, 9.92) and dyslipidemia (OR 1.87, 95% CI 1.15, 3.03) in adolescents who were overweight. Among adolescents with obesity, C-DII quartile was associated with higher SBP (β = 5.07, 95% CI 2.55-7.59) and lower DBP (β = -4.14, 95% CI -6.74, -1.54).
Consuming a pro-inflammatory diet in adolescence was associated with alterations in albuminuria, lipid and BP measures.
儿童膳食炎症指数（C-DII）已被验证可用于描述个体儿童饮食的炎症潜力。
确定 C-DII 与青少年心血管代谢风险标志物（肥胖、血压[BP]、血脂、白蛋白尿、肾小球高滤过）之间的关系。
本横断面研究纳入了 2005 年至 2014 年期间参加 NHANES 且完成 24 小时膳食回忆的 12-18 岁青少年。回归模型调整了年龄、性别、种族和身高，以研究按体重状况分层的 C-DII 四分位数的关联。
在青少年（平均年龄 15 岁）中，平均 C-DII 评分 0.86（SE 0.04）。将 C-DII 四分位数 4（最具炎症性）与四分位数 1（最具抗炎性）进行比较，发现与白蛋白尿呈正相关（OR 1.44，95%CI 1.02，2.03）。按体重状况分层后，发现 C-DII 四分位数与超重青少年的白蛋白尿（OR 4.27，95%CI 1.83，9.92）和血脂异常（OR 1.87，95%CI 1.15，3.03）显著相关。在肥胖青少年中，C-DII 四分位数与较高的 SBP（β=5.07，95%CI 2.55-7.59）和较低的 DBP（β=-4.14，95%CI -6.74，-1.54）相关。
青少年时期摄入促炎饮食与白蛋白尿、血脂和血压指标的改变有关。
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