• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

急性和早期 HIV 感染者的快速抗逆转录病毒治疗。

Rapid Antiretroviral Therapy Among Individuals With Acute and Early HIV.

机构信息

Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, USA.

University of Central Florida College of Medicine, Orlando, Florida, USA.

出版信息

Clin Infect Dis. 2021 Jul 1;73(1):130-133. doi: 10.1093/cid/ciaa1174.

DOI:10.1093/cid/ciaa1174
PMID:32777035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8246801/
Abstract

HIV transmission is increased during acute and early HIV (AEH). Rapid antiretroviral therapy may shorten the duration of infectivity. We show rapid antiretroviral therapy in AEH is acceptable and effective, with 69.0% of participants starting ART within 7 days of HIV diagnosis disclosure, and 88.1% achieving suppression by 48 weeks.

摘要

艾滋病毒传播在急性和早期艾滋病毒(AEH)期间增加。快速抗逆转录病毒治疗可能会缩短感染期。我们表明,AEH 中的快速抗逆转录病毒治疗是可以接受且有效的,有 69.0%的参与者在 HIV 诊断披露后 7 天内开始接受 ART,并且 88.1%的人在 48 周时达到抑制。

相似文献

1
Rapid Antiretroviral Therapy Among Individuals With Acute and Early HIV.急性和早期 HIV 感染者的快速抗逆转录病毒治疗。
Clin Infect Dis. 2021 Jul 1;73(1):130-133. doi: 10.1093/cid/ciaa1174.
2
Outcomes of acutely HIV-1-infected individuals following rapid antiretroviral therapy initiation.急性HIV-1感染个体在快速启动抗逆转录病毒治疗后的结果。
Antivir Ther. 2017;22(1):77-80. doi: 10.3851/IMP3080. Epub 2016 Sep 2.
3
Antiretroviral Therapy Availability and HIV Disclosure to Spouse in Rakai, Uganda: A Longitudinal Population-Based Study.乌干达拉凯地区抗逆转录病毒疗法的可及性及向配偶披露感染艾滋病毒情况:一项基于人群的纵向研究
J Acquir Immune Defic Syndr. 2015 Jun 1;69(2):241-7. doi: 10.1097/QAI.0000000000000600.
4
Rapid HIV Viral Load Suppression in those Initiating Antiretroviral Therapy at First Visit after HIV Diagnosis.HIV 诊断后首次就诊即开始抗逆转录病毒治疗者的 HIV 病毒载量快速抑制。
Sci Rep. 2016 Sep 6;6:32947. doi: 10.1038/srep32947.
5
Sexual risk behaviors among HIV-patients receiving antiretroviral therapy in Southern Thailand: roles of antiretroviral adherence and serostatus disclosure.泰国南部接受抗逆转录病毒治疗的艾滋病毒患者的性风险行为:抗逆转录病毒治疗依从性和血清学状态披露的作用。
AIDS Care. 2016;28(5):612-9. doi: 10.1080/09540121.2015.1120856. Epub 2015 Dec 14.
6
A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa.在南非夸祖鲁-纳塔尔省,比较自我报告与抗逆转录病毒检测,以了解抗逆转录病毒治疗覆盖率、病毒载量抑制情况及艾滋病毒发病率的估计值。
BMC Infect Dis. 2017 Sep 29;17(1):653. doi: 10.1186/s12879-017-2740-y.
7
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.用于治疗符合抗逆转录病毒治疗条件的孕妇艾滋病毒感染的抗逆转录病毒疗法。
Cochrane Database Syst Rev. 2010 Mar 17(3):CD008440. doi: 10.1002/14651858.CD008440.
8
Disclosure amongst adult HIV patients on antiretroviral therapy in Port Harcourt, Nigeria.尼日利亚哈科特港接受抗逆转录病毒治疗的成年艾滋病病毒患者中的信息披露情况。
Int J STD AIDS. 2015 Sep;26(10):729-32. doi: 10.1177/0956462414552815. Epub 2014 Sep 22.
9
Food insecurity, drug resistance and non-disclosure are associated with virologic non-suppression among HIV pregnant women on antiretroviral treatment.抗逆转录病毒治疗的 HIV 孕妇中,食物不安全、耐药性和不披露与病毒学抑制失败相关。
PLoS One. 2021 Aug 18;16(8):e0256249. doi: 10.1371/journal.pone.0256249. eCollection 2021.
10
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.在感染HIV的非洲婴儿中采用三类抗逆转录病毒疗法实现早期病毒学抑制
AIDS. 2008 Jul 11;22(11):1333-43. doi: 10.1097/QAD.0b013e32830437df.

引用本文的文献

1
Rapid Start of HIV Antiretroviral Therapy in New York State.纽约州快速启动艾滋病毒抗逆转录病毒治疗
AIDS Behav. 2025 Jun;29(6):1910-1919. doi: 10.1007/s10461-025-04658-2. Epub 2025 Mar 24.
2
Analysis of Clinical Outcomes Following Implementation of a Rapid Antiretroviral Therapy Initiation Protocol at a Local HIV Clinic.当地一家艾滋病毒诊所实施快速抗逆转录病毒治疗启动方案后的临床结果分析
AIDS Behav. 2025 Apr;29(4):1340-1351. doi: 10.1007/s10461-024-04607-5. Epub 2025 Jan 20.
3
Association between where men who have sex with men (MSM) meet sexual partners and chlamydia/gonorrhoea infection before and during the COVID-19 pandemic in San Diego, California.在加利福尼亚州圣地亚哥,男男性行为者(MSM)在新冠疫情前后与性伴侣见面的地点与衣原体/淋病感染之间的关联。
Sex Transm Infect. 2023 Dec;99(8):527-533. doi: 10.1136/sextrans-2022-055591. Epub 2023 Jul 4.
4
Assessing the reliability of the CD4 depletion model in the presence of Ending the HIV Epidemic initiatives.评估在终结艾滋病毒流行倡议背景下 CD4 细胞耗竭模型的可靠性。
AIDS. 2023 Aug 1;37(10):1617-1624. doi: 10.1097/QAD.0000000000003614. Epub 2023 May 31.
5
Rapid start antiretroviral therapies for improved engagement in HIV care: implementation science evaluation protocol.快速起始抗逆转录病毒疗法提高 HIV 护理参与度:实施科学评估方案。
BMC Health Serv Res. 2023 May 17;23(1):503. doi: 10.1186/s12913-023-09500-w.
6
Assessment of POC CD4 Detecting Mode in District or County Labs - Jiangsu Province, China, 2021.2021年中国江苏省县区实验室即时检测CD4检测模式评估
China CDC Wkly. 2022 Nov 25;4(47):1059-1065. doi: 10.46234/ccdcw2022.213.
7
Immediate ART and clinical outcomes in New York City among patients newly diagnosed with HIV.在纽约市新诊断出 HIV 的患者中,即刻 ART 及临床结局。
AIDS Care. 2023 Apr;35(4):545-554. doi: 10.1080/09540121.2022.2104799. Epub 2022 Jul 27.
8
Virological and Immunological Outcomes of an Intensified Four-Drug versus a Standard Three-Drug Antiretroviral Regimen, Both Integrase Strand Transfer Inhibitor-Based, in Primary HIV Infection.基于整合酶链转移抑制剂的强化四联抗逆转录病毒疗法与标准三联抗逆转录病毒疗法在原发性HIV感染中的病毒学和免疫学结果
Pharmaceuticals (Basel). 2022 Mar 26;15(4):403. doi: 10.3390/ph15040403.
9
The Underrated Salivary Virome of Men Who Have Sex With Men Infected With HIV.男男性行为人群中被低估的唾液病毒组与 HIV 感染。
Front Immunol. 2021 Dec 2;12:759253. doi: 10.3389/fimmu.2021.759253. eCollection 2021.
10
Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA.多重串联的猴免疫缺陷病毒特异性 RNA 引导的 Cas9 切口酶使前病毒 DNA 失活。
J Virol. 2021 Nov 9;95(23):e0088221. doi: 10.1128/JVI.00882-21. Epub 2021 Sep 22.

本文引用的文献

1
I wanted it as soon as possible: a qualitative exploration of reactions to access to same-day ART start among participants in San Diego's ART-NET project.我希望尽快实现:对圣地亚哥抗逆转录病毒治疗网络(ART-NET)项目参与者对当日开始抗逆转录病毒治疗(ART)的反应进行定性探索。
AIDS Care. 2020 Sep;32(9):1191-1197. doi: 10.1080/09540121.2019.1687831. Epub 2019 Nov 12.
2
Rapid initiation of antiretroviral therapy for people living with HIV.为艾滋病毒感染者迅速启动抗逆转录病毒治疗。
Cochrane Database Syst Rev. 2019 Jun 17;6(6):CD012962. doi: 10.1002/14651858.CD012962.pub2.
3
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.通过即时治疗超急性 HIV-1 感染来增强 HIV 特异性 T 细胞功能。
Sci Transl Med. 2019 May 22;11(493). doi: 10.1126/scitranslmed.aau0528.
4
Long-term Therapeutic Impact of the Timing of Antiretroviral Therapy in Patients Diagnosed With Primary Human Immunodeficiency Virus Type 1 Infection.原发性人类免疫缺陷病毒 1 型感染患者抗逆转录病毒治疗时机对长期疗效的影响。
Clin Infect Dis. 2018 May 2;66(10):1519-1527. doi: 10.1093/cid/cix1068.
5
Benefits and risks of rapid initiation of antiretroviral therapy.抗逆转录病毒治疗的快速启动的获益与风险。
AIDS. 2018 Jan 2;32(1):17-23. doi: 10.1097/QAD.0000000000001671.
6
The Effect of Same-Day Observed Initiation of Antiretroviral Therapy on HIV Viral Load and Treatment Outcomes in a US Public Health Setting.美国公共卫生环境下当日观察性启动抗逆转录病毒疗法对HIV病毒载量及治疗结果的影响
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):44-51. doi: 10.1097/QAI.0000000000001134.
7
Antiretroviral Therapy for the Prevention of HIV-1 Transmission.抗逆转录病毒疗法预防HIV-1传播
N Engl J Med. 2016 Sep 1;375(9):830-9. doi: 10.1056/NEJMoa1600693. Epub 2016 Jul 18.
8
Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy.早期抗逆转录病毒治疗可增强 CD4+ T 细胞恢复。
N Engl J Med. 2013 Jan 17;368(3):218-30. doi: 10.1056/NEJMoa1110187.
9
Lower-sensitivity and avidity modifications of the vitros anti-HIV 1+2 assay for detection of recent HIV infections and incidence estimation.降低 Vitros Anti-HIV 1+2 检测试剂的敏感性和亲和力以检测近期 HIV 感染和估计发病率。
J Clin Microbiol. 2012 Dec;50(12):3968-76. doi: 10.1128/JCM.01454-12. Epub 2012 Oct 3.
10
Detection of recent HIV-1 infection using a new limiting-antigen avidity assay: potential for HIV-1 incidence estimates and avidity maturation studies.利用新的限性抗原亲和力测定法检测近期 HIV-1 感染:用于 HIV-1 发病率估计和亲和力成熟研究的潜力。
PLoS One. 2012;7(3):e33328. doi: 10.1371/journal.pone.0033328. Epub 2012 Mar 27.