Department of Biology, Hanoi National University of Education, 136 Xuan Thuy Street, Hanoi, 100000, Vietnam.
National Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, 112807, Vietnam.
Lipids. 2020 Nov;55(6):683-691. doi: 10.1002/lipd.12270. Epub 2020 Aug 10.
Apolipoprotein A-V encoded by apolipoprotein 5 (APOA5) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the APOA5-rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity-related traits (body mass index, waist circumference, hip circumference, and waist-to-hip ratio) on this association. A case-control study was conducted with a total of 154 dyslipidemia cases and 389 controls at the age of 6 to 10 recruited at 31 primary schools in Hanoi city of Vietnam. Genotype for APOA5-rs662799 polymorphism was determined by the restriction fragment length polymorphism analysis. The association of APOA5-rs662799 polymorphism with dyslipidemia adjusting for age, sex, residence, and obesity-related traits was analyzed by binary logistic regression analysis. The results showed that in comparison with T/T and T/C carriers, the C/C carriers had a higher concentration of serum TAG in cases (p =0.049). Carriers of the C allele (C/C + T/C) had higher risk for developing dyslipidemia and hypertriglyceridemia than subjects with T/T genotype (odds ratio, OR = 1.7, p =0.0062 and OR = 1.6, p = 0.026, respectively). The association remained significant after adjusting for age, gender, residence, and obesity status (OR = 1.75, p = 0.006 and OR = 1.53, p = 0.049, respectively) or other obesity-related traits. The study suggested that the APOA5-rs662799 polymorphism may be a determinant of dyslipidemia and hypertriglyceridemia in Vietnamese children, independent of obesity-related traits.
载脂蛋白 A-V 由载脂蛋白 5（APOA5）基因编码，在脂质代谢中发挥重要作用，特别是在调节血浆甘油三酯水平方面。本研究旨在评估越南儿童载脂蛋白 A5-rs662799 多态性与血脂异常的相关性，以及肥胖相关特征（体重指数、腰围、臀围和腰臀比）对这种相关性的潜在修饰作用。采用病例对照研究设计，在越南首都河内的 31 所小学共招募了 154 名血脂异常病例和 389 名对照，年龄为 6-10 岁。通过限制性片段长度多态性分析确定载脂蛋白 A5-rs662799 多态性的基因型。采用二元逻辑回归分析调整年龄、性别、居住地和肥胖相关特征后，分析载脂蛋白 A5-rs662799 多态性与血脂异常的相关性。结果显示，与 T/T 和 T/C 携带者相比，C/C 携带者的血清 TAG 浓度更高（p=0.049）。C 等位基因（C/C+T/C）携带者发生血脂异常和高甘油三酯血症的风险高于 T/T 基因型携带者（比值比，OR=1.7，p=0.0062 和 OR=1.6，p=0.026）。调整年龄、性别、居住地和肥胖状况后，这种关联仍然显著（OR=1.75，p=0.006 和 OR=1.53，p=0.049），或调整其他肥胖相关特征后，这种关联仍然显著。本研究表明，载脂蛋白 A5-rs662799 多态性可能是越南儿童血脂异常和高甘油三酯血症的决定因素，独立于肥胖相关特征。
