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负性情绪的昼夜节律:对心境障碍的影响。

Circadian rhythm in negative affect: Implications for mood disorders.

机构信息

Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA; Oregon Institute of Occupational Health Sciences, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA; VA Portland Health Care System, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA.

Oregon Institute of Occupational Health Sciences, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.

出版信息

Psychiatry Res. 2020 Nov;293:113337. doi: 10.1016/j.psychres.2020.113337. Epub 2020 Aug 4.

Abstract

In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

摘要

在人类中,情绪存在内源性的近 24 小时(即昼夜)变化,最佳情绪出现在昼夜周期白天,最差情绪出现在昼夜周期夜晚。只有积极情绪,而不是消极情绪,被证明与这种昼夜节律有关。我们发现,消极情绪在昼夜周期夜晚出现明显的昼夜高峰,与积极情绪的昼夜低谷相一致。这些发现可能有助于解释抑郁症与失眠、夜间觉醒时自杀风险增加以及昼夜节律失调与重度抑郁症症状严重程度之间的相关性。

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