Yuan Ye, Hou Weiying, Qin Weiping, Wu Changfeng
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, China.
Biomater Sci. 2021 Jan 21;9(2):328-346. doi: 10.1039/d0bm01038c. Epub 2020 Aug 11.
Optical probes that specifically and sensitively change the optical properties upon contact with targets have become irreplaceable tools in fundamental biology and medicine. Semiconducting polymer dots (Pdots) have emerged as popular optical nanoplatforms because of their excellent characteristics, such as tunable luminescence, high brightness, superior stability and biocompatibility, for biological applications. In particular, facile surface and intra-particle modifications enable Pdots to detect various biological parameters, such as reactive oxygen species (ROS), typical metal ions, pH values, temperature and a variety of biomolecules. In this review, we provide a brief overview of the preparation and bio-functionalization strategies of Pdots. This review focuses on the applications of Pdots as optical probes in biosensors and describes the challenges in this field.
与目标接触时能特异性且灵敏地改变光学性质的光学探针，已成为基础生物学和医学中不可或缺的工具。半导体聚合物点（Pdots）因其具有诸如可调谐发光、高亮度、卓越稳定性和生物相容性等优异特性，已成为用于生物应用的热门光学纳米平台。特别是，简便的表面和颗粒内修饰使Pdots能够检测各种生物参数，如活性氧（ROS）、典型金属离子、pH值、温度以及多种生物分子。在本综述中，我们简要概述了Pdots的制备和生物功能化策略。本综述重点关注Pdots作为光学探针在生物传感器中的应用，并描述了该领域面临的挑战。
