Department of Biomedical Engineering, School of Basic Medical Sciences, Central South University, Changsha 410013, China.
Biosensors (Basel). 2023 Jan 14;13(1):137. doi: 10.3390/bios13010137.
In recent years, semiconducting polymer dots (Pdots) have attracted much attention due to their excellent photophysical properties and applicability, such as large absorption cross section, high brightness, tunable fluorescence emission, excellent photostability, good biocompatibility, facile modification and regulation. Therefore, Pdots have been widely used in various types of sensing and imaging in biological medicine. More importantly, the recent development of Pdots for point-of-care biosensing and in vivo imaging has emerged as a promising class of optical diagnostic technologies for clinical applications. In this review, we briefly outline strategies for the preparation and modification of Pdots and summarize the recent progress in the development of Pdots-based optical probes for analytical detection and biomedical imaging. Finally, challenges and future developments of Pdots for biomedical applications are given.
近年来，半导体聚合物点（Pdots）因其优异的光物理性质和适用性而备受关注，例如大的吸收截面、高亮度、可调荧光发射、优异的光稳定性、良好的生物相容性、易于修饰和调节。因此，Pdots 已广泛应用于生物医学中的各种传感和成像。更重要的是，Pdots 在即时检测生物传感和体内成像方面的最新发展已成为一类有前途的用于临床应用的光学诊断技术。在本文综述中，我们简要概述了 Pdots 的制备和修饰策略，并总结了基于 Pdots 的光学探针在分析检测和生物医学成像方面的最新进展。最后，给出了 Pdots 在生物医学应用中的挑战和未来发展方向。
