Biocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-909, Brazil.
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ, 21941-170, CEP, 21941-910, Brazil.
Chemistry. 2021 Mar 26;27(18):5577-5600. doi: 10.1002/chem.202002887. Epub 2021 Jan 31.
The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its phytotherapeutic research. Recently, some countries have included CBD as an antiepileptic product for compassionate use in children with refractory epilepsy. The growing demand for CBD has led to the need for high-purity cannabinoids on the emerging market. The discovery and development of approaches toward CBD synthesis have arisen from the successful extraction of Cannabis plants for cannabinoid fermentation in brewer's yeast. To understand different contributions to the design and enhancement of the synthesis of CBD and its key intermediates, a detailed analysis of the history behind cannabinoid compounds and their optimization is provided herein.
目前，有关大麻二酚（CBD）及其健康影响的证据和建议状况正在改变法律格局，并旨在消除其植物疗法研究的污名化。最近，一些国家已将 CBD 纳入抗癫痫药物范畴，用于同情用药，以治疗耐药性癫痫的儿童。对 CBD 的需求不断增长，导致新兴市场对高纯度大麻素的需求增加。CBD 合成方法的发现和发展源于从大麻植物中成功提取出大麻素，用于啤酒酵母中的发酵。为了了解在 CBD 及其关键中间体的合成设计和改进方面的不同贡献，本文详细分析了大麻素化合物的历史及其优化。
