Department of Civil and Environmental Engineering, Pusan National University, Busan, 46241, Republic of Korea.
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Tissue Eng Regen Med. 2023 Apr;20(2):177-198. doi: 10.1007/s13770-022-00510-z. Epub 2023 Jan 23.
Recently, various attempts have been made to apply diverse types of nanoparticles in biotechnology. Silica nanoparticles (SNPs) have been highlighted and studied for their selective accumulation in diseased parts, strong physical and chemical stability, and low cytotoxicity. SNPs, in particular, are very suitable for use in drug delivery and bioimaging, and have been sought as a treatment for ischemic diseases. In addition, mesoporous silica nanoparticles have been confirmed to efficiently deliver various types of drugs owing to their porous structure. Moreover, there have been innovative attempts to treat ischemic diseases using SNPs, which utilize the effects of Si ions on cells to improve cell viability, migration enhancement, and phenotype modulation. Recently, external stimulus-responsive treatments that control the movement of magnetic SNPs using external magnetic fields have been studied. This review addresses several original attempts to treat ischemic diseases using SNPs, including particle synthesis methods, and presents perspectives on future research directions.
最近，人们尝试将各种类型的纳米粒子应用于生物技术领域。硅纳米粒子（SNPs）因其在病变部位的选择性积累、较强的物理化学稳定性和低细胞毒性而备受关注和研究。特别是 SNPs 非常适合用于药物输送和生物成像，并已被尝试用于治疗缺血性疾病。此外，介孔硅纳米粒子由于其多孔结构已被证实能够有效地输送各种类型的药物。此外，人们还创新性地尝试利用 SNPs 治疗缺血性疾病，利用 Si 离子对细胞的作用来提高细胞活力、促进细胞迁移和调节表型。最近，人们研究了利用外部磁场控制磁性 SNPs 运动的外部刺激响应治疗方法。本综述介绍了使用 SNPs 治疗缺血性疾病的几种原始尝试，包括粒子合成方法，并对未来的研究方向提出了展望。
