Antimicrobial -Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria.

New antimicrobial agents are needed to address infections caused by multidrug-resistant bacteria. Here, we are reporting novel -alkyl derivatives of naringenin and their oximes, including novel compounds with a naringenin core and -hexyl chains, showing activity against clinical strains of clarithromycin-resistant , vancomycin-resistant , methicillin-resistant , and beta-lactam-resistant and The minimum inhibitory concentrations (MICs), which provide a quantitative measure of antimicrobial activity, were in the low microgram range for the selected compounds. Checkerboard assays for the most active compounds in combination with antibiotics revealed interactions that varied from synergistic to neutral.