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柑橘类黄酮作为抗菌剂

Citrus Flavonoids as Antimicrobials.

作者信息

Ciriminna Rosaria, Petri Giovanna Li, Angellotti Giuseppe, Luque Rafael, Fabiano Tixier Anne-Sylvie, Meneguzzo Francesco, Pagliaro Mario

机构信息

Istituto per lo Studio dei Materiali Nanostrutturati, CNR, Palermo, Italy.

Universidad Espíritu Santo (UEES), Samborondón, Ecuador.

出版信息

Chem Biodivers. 2025 Jun;22(6):e202403210. doi: 10.1002/cbdv.202403210. Epub 2025 Mar 13.

DOI:10.1002/cbdv.202403210
PMID:39898883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12168191/
Abstract

Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant, antimicrobial, anti-inflammatory, mitoprotective, and neuroprotective activity. Research on their broad-scope bioactivity experienced a renaissance in the early 2000s, and further accelerated after COVID-19, including research on their antimicrobial properties. Summarizing selected research achievements on the antimicrobial activity of the main Citrus flavonoids, this study aims to provide a unified picture on the antimicrobial properties of these valued compounds that will hopefully assist in the development of flavonoid-based antimicrobials, including antibacterial treatments suitable for clinical use minimizing antimicrobial resistance.

摘要

柑橘类黄酮是具有高度生物活性的化合物，具有多种健康益处，包括抗癌、抗氧化、抗菌、抗炎、线粒体保护和神经保护活性。对其广泛生物活性的研究在21世纪初经历了复兴，并在新冠疫情后进一步加速，包括对其抗菌特性的研究。本研究总结了主要柑橘类黄酮抗菌活性的部分研究成果，旨在对这些有价值化合物的抗菌特性提供一个统一的认识，有望有助于开发基于类黄酮的抗菌剂，包括适用于临床使用且能尽量减少抗菌耐药性的抗菌治疗方法。

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Naringin exerts antibacterial and anti-inflammatory effects on mice with Staphylococcus aureus-induced osteomyelitis.柚皮苷对金黄色葡萄球菌诱导的骨髓炎小鼠具有抗菌和抗炎作用。
J Biochem Mol Toxicol. 2024 Jul;38(7):e23753. doi: 10.1002/jbt.23753.
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Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus.
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The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose-response meta-analysis of randomized clinical trials.柑橘类黄酮补充剂对血管内皮功能的影响：一项随机临床试验的系统评价和剂量反应荟萃分析。
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