Sung Y F, Kutner M H, Cerine F C, Frederickson E L
Anesth Analg. 1977 Jul-Aug;56(4):473-8. doi: 10.1213/00000539-197707000-00001.
The analgesic effects of acupuncture were compared with those of codeine in the treatment of postoperative dental pain in 40 healthy male volunteers 18 to 30 years old. Upon the patient's recovery from local anesthesia (lidocaine), he was asked by a trained observer to classify the intensity of his pain as none, mild, moderate, or severe. He then received one of the following treatments: 1. Placebo: lactose, plus acupuncture placebo 2. Codeine: codeine, plus acupuncture placebo 3. Acupuncture (Ho-Ku): lactose, plus 2 Ho-Ku points 4. Codeine-acupuncture: codeine, plus 2 Ho-Ku points. The pain intensity score was recorded by the observer at half-hour intervals for 3 hours. Patients in treatment groups 2, 3 and 4 showed significantly greater pain relief than those in treatment group 1. For the 1st half hour, there was more pain relief with Ho-Ku alone than with codeine plus Ho-Ko (p less than 0.01). However, for the 2, 2 1/2, and 3-hour periods, codeine plus Ho-Ku produced more pain relief than any of the other treatments.
在40名年龄在18至30岁的健康男性志愿者中，比较了针刺与可待因治疗术后牙痛的镇痛效果。患者从局部麻醉（利多卡因）恢复后，由一名经过培训的观察者要求其将疼痛强度分为无、轻度、中度或重度。然后，他接受以下治疗之一：1. 安慰剂：乳糖加针刺安慰剂；2. 可待因：可待因加针刺安慰剂；3. 针刺（合谷）：乳糖加两个合谷穴；4. 可待因 - 针刺：可待因加两个合谷穴。观察者每隔半小时记录一次疼痛强度评分，持续3小时。治疗组2、3和4的患者疼痛缓解程度明显大于治疗组1。在第一个半小时，单独针刺合谷穴比可待因加合谷穴的止痛效果更好（p小于0.01）。然而，在2小时、2个半小时和3小时期间，可待因加合谷穴比其他任何治疗方法产生的止痛效果都更好。
