Giglio J A, Laskin D M
Department of Oral and Maxillofacial Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0566.
J Oral Maxillofac Surg. 1990 Aug;48(8):785-90. doi: 10.1016/0278-2391(90)90332-v.
A single-dose, randomized, double-blind, parallel-treatment study was performed in 200 outpatients with acute pain caused by the surgical removal of impacted third molars. Meclofenamate 100 mg plus codeine 60 mg, meclofenamate 50 mg plus codeine 30 mg, meclofenamate 100 mg, codeine 60 mg, and placebo treatment groups were compared for sum of pain intensity differences, peak pain intensity difference, sum of pain relief scores, peak pain relief, number of observations at which pain was half relieved, overall evaluation of effectiveness, and time to remedication with a backup analgesic. Meclofenamate 100 mg plus codeine 60 mg was significantly more effective (P less than .005) than codeine 60 mg for all variables except number of observations at which pain was half relieved. Both meclofenamate-codeine combinations and meclofenamate 100 mg alone were significantly more effective (P less than .005) than placebo for all variables. Eleven adverse experiences were reported in 7 patients (3.5%); the most common was somnolence in 1 patient receiving meclofenamate 100 mg plus codeine 60 mg, in 2 treated with meclofenamate 50 mg plus codeine 30 mg, and in 1 treated with codeine 60 mg.
对200名因拔除阻生第三磨牙手术引起急性疼痛的门诊患者进行了一项单剂量、随机、双盲、平行治疗研究。比较了100毫克甲氯芬那酸加60毫克可待因、50毫克甲氯芬那酸加30毫克可待因、100毫克甲氯芬那酸、60毫克可待因和安慰剂治疗组在疼痛强度差异总和、峰值疼痛强度差异、疼痛缓解评分总和、峰值疼痛缓解、疼痛减轻一半时的观察次数、有效性总体评估以及使用备用镇痛药再次用药时间等方面的情况。除疼痛减轻一半时的观察次数外，100毫克甲氯芬那酸加60毫克可待因在所有变量上均比60毫克可待因显著更有效（P小于0.005）。甲氯芬那酸 - 可待因组合以及单独使用100毫克甲氯芬那酸在所有变量上均比安慰剂显著更有效（P小于0.005）。7名患者（3.5%）报告了11次不良事件；最常见的是1名接受100毫克甲氯芬那酸加60毫克可待因治疗的患者、2名接受50毫克甲氯芬那酸加30毫克可待因治疗的患者以及1名接受60毫克可待因治疗的患者出现嗜睡。
