Department of Radiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Rd, Zhengzhou 450008, China.
Department of Radiology, the First People's Hospital of Shangqiu, 292 South Kaixuan Rd, Shangqiu 476100, China.
Int J Med Sci. 2020 Jul 19;17(13):1909-1915. doi: 10.7150/ijms.46688. eCollection 2020.
To retrospectively compare the clinical features and chest computed tomography (CT) characteristics of coronavirus disease 2019 (COVID-19) and pneumonia in lymphoma patients. Ten lymphoma patients with pneumonia and 12 patients with COVID-19 infections were enrolled from January 15 to March 14, 2020. The clinical features were recorded. All pulmonary lesions on chest CT were assessed for location, shape, density and diffusion degree. Other typical CT features were also evaluated. The most commonly observed patchy lesions were ground-glass opacities (GGOs) and mixed GGOs in both groups. Regarding the diffusion degree, 82% (92/112) of the lesions in the COVID-19 group were relatively limited, while 69% (52/75) of those in the lymphoma group were diffuse ( < 0.001). The proportions of interlobular septal thickening, vascular thickening, pleural involvement and fibrous stripes observed in the lymphoma cases were statistically compatible with those observed in the COVID-19 cases ( 0.05). Air bronchograms were observed more frequently in COVID-19 patients (45%, 50/112) than in lymphoma patients with pneumonia (5%, 4/75) ( < 0.001). Halo sign (6%) and reversed halo sign (1%) were observed in several COVID-19 patients but not in lymphoma-associated pneumonia patients. Both lymphoma-associated pneumonia and COVID-19 generally manifested as patchy GGOs and mixed GGOs in more than one lobe. Compared to COVID-19, lymphoma-associated pneumonia tended to be relatively diffuse, with fewer air bronchograms, and no halo or reversed halo signs observed on chest CT.
回顾性比较淋巴瘤患者肺炎和 2019 年冠状病毒病（COVID-19）的临床特征和胸部计算机断层扫描（CT）特征。2020 年 1 月 15 日至 3 月 14 日期间，共纳入 10 例淋巴瘤合并肺炎患者和 12 例 COVID-19 感染患者。记录临床特征。评估所有肺部 CT 病变的位置、形状、密度和扩散程度。还评估了其他典型 CT 特征。两组最常见的斑片状病变均为磨玻璃影（GGO）和混合 GGO。关于扩散程度，COVID-19 组 82%（92/112）的病变相对局限，而淋巴瘤组 69%（52/75）的病变弥漫（<0.001）。观察到的间质性小叶间隔增厚、血管增厚、胸膜受累和纤维条纹的比例在淋巴瘤病例中与 COVID-19 病例中观察到的比例统计学一致（0.05）。空气支气管征在 COVID-19 患者中更常见（45%，50/112），而在淋巴瘤肺炎患者中较少见（5%，4/75）（<0.001）。在几位 COVID-19 患者中观察到晕征（6%）和反向晕征（1%），但在淋巴瘤相关肺炎患者中未观察到。淋巴瘤相关肺炎和 COVID-19 通常在一个以上肺叶表现为斑片状 GGO 和混合 GGO。与 COVID-19 相比，淋巴瘤相关肺炎往往较为弥漫，空气支气管征较少，胸部 CT 未见晕征或反向晕征。
