Lancaster Jordan J, Koevary Jen Watson, Chinyere Ikeotunye Royal, Daugherty Sherry L, Fox Kenneth A, Goldman Steven
Sarver Heart Center, University of Arizona, Tucson, AZ 85724, United States.
Department of Medicine, University of Arizona, Tucson, AZ 85724, United States.
Vessel Plus. 2019;3. doi: 10.20517/2574-1209.2019.16. Epub 2019 Sep 17.
This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mechanisms of action, autologous . allogeneic cell approaches, immunologic modulation, and safety considerations. We will outline the progress that has been made to-date and define the areas that still need to be investigated in order to advance the field.
本综述将概述针对心力衰竭的细胞疗法，重点关注通过组织工程将细胞递送至受损心脏。我们将概述主要方法，重点关注多能干细胞衍生细胞、作用机制、自体和异体细胞方法、免疫调节以及安全考量。我们将概述迄今为止所取得的进展，并确定为推动该领域发展仍需研究的领域。
