Department of Ophthalmology, Military Medical Academy, 21/1, Botkinskaya St, 194044, St Petersburg, Russia.
University of Pittsburgh, UPMC Eye Center, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.
Graefes Arch Clin Exp Ophthalmol. 2021 Feb;259(2):301-306. doi: 10.1007/s00417-020-04872-9. Epub 2020 Aug 12.
To study the diagnostic potential of retro-mode scanning laser ophthalmoscopy (RM-SLO) for evaluation of peripheral retinal lesions.
Based on the results of indirect ophthalmoscopy, in this study, we included asymptomatic subjects with lattice retinal degeneration, retinal break, or subclinical retinal detachment and subjects without any peripheral retinal lesions. All participants' fundus periphery was examined with RM-SLO over 360° for the presence of peripheral retinal lesions in a masked fashion. Detection rate for retinal breaks and detachments were compared between indirect ophthalmoscopy and RM-SLO.
Twenty-six subjects (52 eyes, 15 males and 11 females, 34.8 ± 11.8 years) were included in the peripheral retinal lesion group and 25 individuals (50 eyes, 10 males and 15 females, 42.8 ± 14.5 years) were included in the group without peripheral retinal lesions. Among the patients with peripheral retinal lesions detected with indirect ophthalmoscopy in at least one eye, RM-SLO categorized 20.7% (p = 0.031) more eyes as having subclinical asymptomatic retinal detachment or at least one retinal break. Additionally, RM-SLO demonstrated 55.0% (p = 0.001) more subclinical retinal detachments and 31.5% (p = 0.002) more asymptomatic retinal breaks.
RM-SLO showed high potential in diagnosing peripheral retinal lesions and may be a useful additional diagnostic tool for the patients who demonstrate peripheral retinal lesions with indirect ophthalmoscopy.
研究反转模式扫描激光检眼镜（RM-SLO）在评估周边视网膜病变中的诊断潜力。
基于间接检眼镜的结果，本研究纳入了无症状的伴有格子状视网膜变性、视网膜裂孔或隐匿性视网膜脱离的患者，以及无任何周边视网膜病变的患者。所有参与者均采用 RM-SLO 对周边眼底进行 360°检查，以发现隐匿性周边视网膜病变，检查过程中采用盲法。比较间接检眼镜和 RM-SLO 对视网膜裂孔和脱离的检出率。
纳入了 26 例（52 只眼，15 名男性，11 名女性，34.8±11.8 岁）周边视网膜病变患者和 25 名（50 只眼，10 名男性，15 名女性，42.8±14.5 岁）无周边视网膜病变的患者。在至少一眼通过间接检眼镜检测到周边视网膜病变的患者中，RM-SLO 将 20.7%（p=0.031）更多的眼归类为有隐匿性无症状性视网膜脱离或至少一处视网膜裂孔。此外，RM-SLO 显示出 55.0%（p=0.001）更多的隐匿性视网膜脱离和 31.5%（p=0.002）更多的无症状性视网膜裂孔。
RM-SLO 在诊断周边视网膜病变方面具有很高的潜力，可能是一种有用的附加诊断工具，适用于间接检眼镜显示有周边视网膜病变的患者。
