Kinash M I, Boyarchuk O R
I. Horbachevsky Ternopil National Medical Univetsity, 46001, Ternopil, Ukraine.
Vopr Pitan. 2020;89(3):22-32. doi: 10.24411/0042-8833-2020-10026. Epub 2020 May 18.
The role of vitamins in the formation of the immune response, both innate and acquired immunity, is well known. At the same time, deficit of fat-soluble vitamins A, E, D leads to impaired response of the immune system to the infectious invasion and to disorders of immune system functioning. of this article is to analyze the literature data on the impact of fat-soluble vitamins on the function of the human immune system and the possibilities of their use in patients with immunodeficiency. . Сurrently, there are enough evidences of the successful use of fat-soluble vitamins in secondary immunodeficiencies. Data on the usage of vitamins A, E, D in the treatment of primary immunodeficiencies are few. However, even reducing of antibiotics and other medicines administration in children with primary immunodeficiency indicates the feasibility of their using. The results of scientific studies on the successful use of vitamins D and A in the treatment of allergic diseases, vitamin D in the prevention and improvement of the treatment of autoimmune and oncological diseases indicate the possibility of their use as adjuvant immunomodulatory therapy in children with primary immunodeficiency. Promising may be the use of vitamins A and E, as powerful antioxidants in patients with primary immunodeficiencies with defects in DNA repair processes. . The analysis of the literature data has shown that despite many questions need to be resolved, fat-soluble vitamins A, D, and E, and their analogues can be used in clinical settings to enhance the therapeutic effect in children with immune deficiency.
维生素在先天性和获得性免疫的免疫反应形成中的作用是众所周知的。同时，脂溶性维生素A、E、D的缺乏会导致免疫系统对感染性侵袭的反应受损以及免疫系统功能紊乱。本文的目的是分析关于脂溶性维生素对人体免疫系统功能的影响及其在免疫缺陷患者中应用可能性的文献数据。目前，有足够的证据表明脂溶性维生素在继发性免疫缺陷中成功应用。关于维生素A、E、D用于治疗原发性免疫缺陷的数据很少。然而，即使在原发性免疫缺陷儿童中减少抗生素和其他药物的使用也表明了其使用的可行性。关于维生素D和A成功用于治疗过敏性疾病、维生素D用于预防和改善自身免疫性疾病及肿瘤疾病治疗的科学研究结果表明，它们有可能作为原发性免疫缺陷儿童的辅助免疫调节疗法。对于DNA修复过程存在缺陷的原发性免疫缺陷患者，使用维生素A和E作为强大的抗氧化剂可能很有前景。文献数据分析表明，尽管仍有许多问题需要解决，但脂溶性维生素A、D和E及其类似物可用于临床，以增强免疫缺陷儿童的治疗效果。
