Liao Jianyuan, Zhang Lifang, Chen Gangxin, Luo Yuxing
Department of Blood Transfusion, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Department of Joint Surgery and Sports Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Open Med (Wars). 2024 Jun 7;19(1):20240972. doi: 10.1515/med-2024-0972. eCollection 2024.
Community-acquired pneumonia (CAP) is a common respiratory disease in children. This prospective cohort study of 110 children with CAP and 100 healthy children investigated the relationship between the levels of vitamin A, D and E and inflammatory markers, such as tumour necrosis factor (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophils (NE) and C-reactive protein (CRP), in CAP. The haemoglobin, leukocyte concentration, NE, monocytes and CRP concentration in the CAP group showed significant differences ( < 0.05). The levels of vitamin A, D and E in the CAP group were lower than those in the control group, while the levels of TNF-a and IL-1 were higher than in the control group; the differences were statistically significant ( < 0.05). The IL-10 levels showed no significant differences ( > 0.05). Pearson analysis revealed that the vitamin A, D and E levels were all correlated with the TNF-a, IL-10 and CRP levels ( < 0.05). The vitamin A, D and E levels of the CAP children were lower than those of the healthy children. Thus, the content of fat-soluble vitamins is correlated with the secretion of TNF-a and IL-10. The research provides a new direction for the prevention, diagnosis and treatment of CAP.
社区获得性肺炎（CAP）是儿童常见的呼吸道疾病。这项对110例CAP患儿和100例健康儿童的前瞻性队列研究，调查了维生素A、D和E水平与CAP中炎症标志物之间的关系，这些炎症标志物包括肿瘤坏死因子（TNF-α）、白细胞介素-1（IL-1）、白细胞介素-10（IL-10）、中性粒细胞（NE）和C反应蛋白（CRP）。CAP组的血红蛋白、白细胞浓度、NE、单核细胞和CRP浓度存在显著差异（P<0.05）。CAP组维生素A、D和E水平低于对照组，而TNF-α和IL-1水平高于对照组；差异具有统计学意义（P<0.05）。IL-10水平无显著差异（P>0.05）。Pearson分析显示，维生素A、D和E水平均与TNF-α、IL-10和CRP水平相关（P<0.05）。CAP患儿的维生素A、D和E水平低于健康儿童。因此，脂溶性维生素含量与TNF-α和IL-10的分泌相关。该研究为CAP的预防、诊断和治疗提供了新方向。
