Wang Xiaoling, Ouyang Xumei, Sun Xiaoyi
Department of Pharmacy, Zhejiang University City College, Hangzhou 310015, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018 May 25;47(5):525-533. doi: 10.3785/j.issn.1008-9292.2018.10.13.
In recent years, a large number of studies have achieved tumor targeting by mesenchymal stem cells (MSC)-based delivery system attributed to the tumor tropism of MSCs. Biomacromolecules and antineoplastic drugs loaded on MSC via internalization or cell membrane anchoring can be released or expressed at tumor site to perform their antitumor effects. The genetically modified MSC are extensively studied, however, the applications of MSCs in targeted delivery of antineoplastic drug with small molecules are not well summarized. In this review, MSCs homing mechanism and the distribution of injected MSCs is introduced; the examples of antitumor drug-primed MSCs and drug loaded MSCs are presented; the drug loading and releasing process from MSCs is also illustrated; finally, challenges and future perspectives of MSCs-based drug delivery system on realizing its full potential are prospected.
近年来，大量研究通过基于间充质干细胞（MSC）的递送系统实现了肿瘤靶向，这归因于MSC的肿瘤嗜性。通过内化或细胞膜锚定加载到MSC上的生物大分子和抗肿瘤药物可在肿瘤部位释放或表达，以发挥其抗肿瘤作用。基因修饰的MSC已得到广泛研究，然而，MSC在小分子抗肿瘤药物靶向递送中的应用尚未得到很好的总结。在本综述中，介绍了MSC的归巢机制和注射的MSC的分布；展示了抗肿瘤药物预处理的MSC和载药MSC的实例；还阐述了药物从MSC的加载和释放过程；最后，展望了基于MSC的药物递送系统在充分发挥其潜力方面面临的挑战和未来前景。
