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风湿性多肌痛。泼尼松龙治疗的突然停药和逐渐停药，临床及实验室观察

Polymyalgia rheumatica. Abrupt and gradual withdrawal of prednisolone treatment, clinical and laboratory observations.

作者信息

Esselinckx W, Doherty S M, Dixon A S

出版信息

Ann Rheum Dis. 1977 Jun;36(3):219-24. doi: 10.1136/ard.36.3.219.

DOI:10.1136/ard.36.3.219
PMID:327947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1006669/
Abstract

Eighteen patients with polymyalgia rheumatica had corticosteroid treatment withdrawn abruptly under close observation. In each case polymyalgic symptoms reappeared but were controlled rapidly when prednisolone was reintroduced. Prednisolone withdrawal was then started by slow decrements of dose. In no patient was it possible to withdraw prednisolone treatment, after using either method, during the period of observation.

摘要

18例风湿性多肌痛患者在密切观察下突然停用皮质类固醇治疗。每例患者的多肌痛症状均再次出现，但重新使用泼尼松龙后症状迅速得到控制。随后开始缓慢减量泼尼松龙剂量。在观察期内，无论采用哪种方法，均无法使任何患者停用泼尼松龙治疗。

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本文引用的文献

1
Adrenal function after prolonged corticosteroid therapy.长期皮质类固醇治疗后的肾上腺功能。
Br Med J. 1962 Jun 9;1(5292):1579-84. doi: 10.1136/bmj.1.5292.1579.
2
GIANT-CELL MYOCARDITIS WITH MULTIPLE ORGAN INVOLVEMENT.伴有多器官受累的巨细胞性心肌炎
Arch Intern Med. 1965 Sep;116:444-7. doi: 10.1001/archinte.1965.03870030124022.
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Prognosis in the anarthritic rheumatoid syndrome.非关节炎型类风湿综合征的预后
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Symptomatology resulting from withdrawal of steroid hormone therapy.类固醇激素治疗停药引起的症状学
Arthritis Rheum. 1959 Aug;2:299-321. doi: 10.1002/1529-0131(195908)2:4<299::aid-art1780020403>3.0.co;2-t.
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Giant-cell arteritis, or arteritis of the aged.巨细胞动脉炎，即老年动脉炎。
Br Med J. 1960 Nov 26;2(5212):1562-7. doi: 10.1136/bmj.2.5212.1562.
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Polymyalgia rheumatica. A clinical study of 21 cases.风湿性多肌痛。21例临床研究。
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7
Giant-cell (temporal) arteritis.巨细胞（颞）动脉炎
J Pathol Bacteriol. 1954 Apr;67(2):507-19. doi: 10.1002/path.1700670224.
8
Blood levels of 17-hydroxycorticosteroids following the administration of adrenal steroids and their relation to levels of circulating leukocytes.肾上腺皮质类固醇给药后17-羟皮质类固醇的血药浓度及其与循环白细胞水平的关系。
J Clin Invest. 1952 May;31(9):843-9. doi: 10.1172/JCI102671.
9
Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy.皮质类固醇治疗后下丘脑-垂体-肾上腺功能的恢复
Lancet. 1967 Oct 21;2(7521):856-9. doi: 10.1016/s0140-6736(67)92592-5.
10
Temporal arteritis developing during indomethacin therapy of polymyalgia rheumatica.在风湿性多肌痛的消炎痛治疗期间发生的颞动脉炎。
Can Med Assoc J. 1967 Aug 5;97(6):296-9.