对映体烯丙基醇的反 Markovnikov 氢胺化反应，用于获得手性 γ-氨基醇。
Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral γ-Amino Alcohols.
机构信息
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China.
Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
出版信息
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):21959-21964. doi: 10.1002/anie.202009754. Epub 2020 Sep 30.
A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral γ-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral γ-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 % ee).
本文报道了一种钌催化的烯丙醇的反马氏羟胺化反应，用于合成手性γ-氨基醇。该反应通过不对称氢 borrowing 过程进行，能够使外消旋仲烯丙醇与各种胺反应，以优异的对映选择性（68 个实例，高达 >99%ee）得到对映体富集的手性γ-氨基醇，具有广泛的底物范围。
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