University of Strasbourg, CNRS, ISIS UMR 7006, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Chem Commun (Camb). 2023 Apr 18;59(32):4716-4725. doi: 10.1039/d3cc00551h.
Given that alcohol moieties are present in a great diversity of valuable fine chemicals from nature and synthesis, methods enabling their structure diversification are highly sought after. Catalysis proved to enable the development of new transformations that are beyond the inherent reactivity of alcohols. However, modifying the structure of alcohols at certain unbiased positions remains a major challenge or requires tedious multistep procedures. Recently, increased attention has been given to multicatalyis, which combines multiple reactions and catalysts within one system, creating room for discovering previously inaccessible reactivities or increasing the overall efficiency of multistep transformations. This feature article focuses on demonstrating various aspects of devising such multicatalytic systems that modify the structure of alcohol-containing compounds. Special attention is given to highlighting the challenges and advantages of multicatalysis, and in a broader context discussing how the field of catalysis may progress toward more complex systems.
鉴于醇基在自然界和合成中存在于大量有价值的精细化学品中，因此人们非常需要能够实现其结构多样化的方法。催化已被证明能够开发出超出醇固有反应性的新转化。然而，在某些无偏见的位置修饰醇的结构仍然是一个主要挑战，或者需要繁琐的多步程序。最近，人们越来越关注多催化，它将多个反应和催化剂组合在一个系统中，为发现以前无法获得的反应性或提高多步转化的整体效率创造了空间。本文重点介绍了设计这种改变含醇化合物结构的多催化体系的各个方面。特别关注突出多催化的挑战和优势，并更广泛地讨论催化领域如何朝着更复杂的体系发展。
