通过提供定量T2图谱和合成形态学图像评估宫颈癌特征的新型T2图谱：一项初步研究
Novel T2 Mapping for Evaluating Cervical Cancer Features by Providing Quantitative T2 Maps and Synthetic Morphologic Images: A Preliminary Study.
作者信息
Li Shujian, Liu Jie, Zhang Feifei, Yang Meng, Zhang Zanxia, Liu Jingjing, Zhang Yong, Hilbert Tom, Kober Tobias, Cheng Jingliang, Zhu Jinxia
机构信息
Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.
出版信息
J Magn Reson Imaging. 2020 Dec;52(6):1859-1869. doi: 10.1002/jmri.27297. Epub 2020 Aug 14.
BACKGROUND
The application value of T mapping in evaluating cervical cancer (CC) features remains unclear.
PURPOSE
To investigate the role of T values in evaluating CC classification, grade, and lymphovascular space invasion (LVSI) in comparison to apparent diffusion coefficient (ADC), and to compare synthetic T -weighted (T W) images calculated from T values to conventional T W images for CC staging.
STUDY TYPE
Retrospective.
POPULATION
Sixty-three patients with histopathologically confirmed CC.
FIELD STRENGTH/SEQUENCE: 3T, conventional T W turbo spin-echo, diffusion-weighted echo-planar, and accelerated T mapping sequence.
ASSESSMENT
T and ADC values between different pathological features of CC were compared. The diagnostic accuracies of conventional and synthetic T W images in staging were also compared.
STATISTICAL TESTS
Parameters were compared using an independent t-test, Wilcoxon signed-rank test, and the chi-square test. Receiver operating characteristic analysis was performed.
RESULTS
The T values varied significantly between well/moderately differentiated and poorly differentiated tumors ([92.8 ± 9.5 msec] vs. [83.8 ± 9.5 msec], P < 0.05) and between LVSI-positive and LVSI-negative CC ([82.2 ± 8.2 msec] vs. [93.9 ± 9.1 msec], P < 0.05). The ADC values showed a significant difference for grade ([0.76 ± 0.10 × 10 mm /s] vs. [0.65 ± 0.11 × 10 mm /s], P < 0.05) and no difference for LVSI status ([0.71 ± 0.11× 10 mm /s] vs. [0.73 ± 0.12× 10 mm /s], P = 0.472). There was no significant difference in T and ADC values between squamous cell carcinoma and adenocarcinoma (P = 0.378 and P = 0.661, respectively). In MRI staging, the conventional and synthetic T W images resulted in a similar accuracy (71% vs. 68%, P = 0.698).
DATA CONCLUSION
The accelerated T mapping sequence may facilitate grading and staging of CC by providing quantitative T maps and synthetic T W images in one acquisition. T values may be superior to ADC in predicting LVSI.
LEVEL OF EVIDENCE
2 TECHNICAL EFFICACY STAGE: 2 J. MAGN. RESON. IMAGING 2020;52:1859-1869.
背景
T 映射在评估宫颈癌（CC）特征方面的应用价值尚不清楚。
目的
与表观扩散系数（ADC）相比，研究 T 值在评估 CC 分类、分级和淋巴管间隙浸润（LVSI）中的作用，并将根据 T 值计算的合成 T 加权（T W）图像与传统 T W 图像用于 CC 分期进行比较。
研究类型
回顾性研究。
研究对象
63 例经组织病理学确诊的 CC 患者。
场强/序列：3T，传统 T W 快速自旋回波、扩散加权回波平面成像和加速 T 映射序列。
评估
比较 CC 不同病理特征之间的 T 和 ADC 值。还比较了传统和合成 T W 图像在分期中的诊断准确性。
统计检验
使用独立 t 检验、Wilcoxon 符号秩检验和卡方检验比较参数。进行受试者操作特征分析。
结果
高/中分化与低分化肿瘤之间的 T 值有显著差异（[92.8±9.5 毫秒] 对 [83.8±9.5 毫秒]，P < 0.05），LVSI 阳性与 LVSI 阴性 CC 之间也有显著差异（[82.2±8.2 毫秒] 对 [93.9±9.1 毫秒]，P < 0.05）。ADC 值在分级方面有显著差异（[0.76±0.10×10⁻³ 毫米²/秒] 对 [0.65±0.1
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