局部麻醉药对大肠杆菌外膜通透性的增加及抗生素的渗透
Increase in permeability of Escherichia coli outer membrane by local anesthetics and penetration of antibiotics.
作者信息
Labedan B
机构信息
Institut de Microbiologie, Université Paris-Sud, Orsay, France.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):153-5. doi: 10.1128/AAC.32.1.153.
Abstract
The MICs of several antibiotics (both hydrophobic and hydrophilic) which penetrate very poorly into intact Escherichia coli cells were found to be 2- to 10-fold decreased in the presence of low doses of various local anesthetics (procaine, dibucaine, tetracaine, chlorpromazine, and quinine). The concentrations of anesthetics necessary for this effect have no adverse effect on cell growth and are markedly lower than those concentrations used clinically.
摘要
研究发现，几种疏水性和亲水性抗生素在完整的大肠杆菌细胞中穿透性很差，在低剂量的各种局部麻醉剂（普鲁卡因、丁卡因、丁哌卡因、氯丙嗪和奎宁）存在的情况下，其最低抑菌浓度（MIC）降低了2至10倍。产生这种效果所需的麻醉剂浓度对细胞生长没有不良影响，且明显低于临床使用的浓度。
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