Fazly Bazaz B S, Salt W G
Microbios. 1983;37(147):45-64.
The antibacterial activity of four local anaesthetics (LAs), amethocaine and procaine (esters), and cinchocain and lignocaine (amides), has been studied. All four LAs inhibited cell growth but only amethocaine and cinchocain had significant effects on cell viability and on the leakage of cellular constituents. Effects on growth inhibition were reversible. Concentrations causing marked loss in viability also caused the leakage of cellular constituents. Uptake isotherms for all four LAs by E. coli are presented and an attempt made to relate derived intracellular LA levels with effects on growth inhibition. Cultures of E. coli grown in the presence of low levels of LAs effects reflecting the relative hydrophilic-lipophilic nature of the individual LAs.
研究了四种局部麻醉剂（LA）的抗菌活性，即丁卡因和普鲁卡因（酯类）以及辛可卡因和利多卡因（酰胺类）。所有四种局部麻醉剂均抑制细胞生长，但只有丁卡因和辛可卡因对细胞活力及细胞成分渗漏有显著影响。对生长抑制的影响是可逆的。导致活力显著丧失的浓度也会引起细胞成分的渗漏。给出了大肠杆菌对所有四种局部麻醉剂的摄取等温线，并尝试将所得的细胞内局部麻醉剂水平与对生长抑制的影响联系起来。在低水平局部麻醉剂存在下生长的大肠杆菌培养物反映了各局部麻醉剂相对亲水 - 亲脂的性质。
