Javaid Sadia, Ahmad Hafiz Usman, Lone Khalid Parvez
Department of Physiology, Al-Aleem Medical College, Lahore, Pakistan.
Department of Physiology & Cell Biology, University of Health Sciences, Lahore.
J Pak Med Assoc. 2020 Jul;70(7):1165-1168. doi: 10.5455/JPMA.17126.
To estimate plasma somatostatin and insulin like growth factor-1levels in women with polycystic ovary syndrome, and to compare it with healthy controls.
The cross-sectional comparative study was conducted at the University of Health Sciences (UHS), Lahore, Pakistan, from December 2016 to January 2018, and comprised patients of polycystic ovary syndrome selected from tertiary care hospitals of the city. A group of apparently healthy women was also raised from the local community to work as controls. Anthropometric measurements, general physical examination and fasting blood glucose levels were determined for each subject. Plasma insulin, somatostatin and insulin like growth factor-1levels were estimated using enzyme-linked immunosorbent assay. Data was collected using a predesigned questionnaire and was analysed using SPSS 20.
Of the 80 subjects, 40(50%) were cases with a mean age of 22.63±4.47 years, and 40(50%) were controls with a mean age of 22.78±4.85 years (p>0.05). The cases had higher fasting blood glucose, insulin and insulin like growth factor-1levels (p<0.05) compared to the controls.
Insulin resistance and lower somatostatin levels along with higher insulin like growth factor-1 levels were found in women with polycystic ovary syndrome compared to healthy women.
评估多囊卵巢综合征女性的血浆生长抑素和胰岛素样生长因子-1水平，并与健康对照者进行比较。
2016年12月至2018年1月在巴基斯坦拉合尔健康科学大学开展了一项横断面比较研究，纳入了从该市三级医院选取的多囊卵巢综合征患者。还从当地社区招募了一组看似健康的女性作为对照。对每位受试者进行人体测量、一般体格检查和空腹血糖水平测定。采用酶联免疫吸附测定法评估血浆胰岛素、生长抑素和胰岛素样生长因子-1水平。使用预先设计的问卷收集数据，并采用SPSS 20进行分析。
80名受试者中，40例（50%）为病例组，平均年龄22.63±4.47岁；40例（50%）为对照组，平均年龄22.78±4.85岁（p>0.05）。与对照组相比，病例组的空腹血糖、胰岛素和胰岛素样生长因子-1水平更高（p<0.05）。
与健康女性相比，多囊卵巢综合征女性存在胰岛素抵抗、生长抑素水平较低以及胰岛素样生长因子-1水平较高的情况。
