胱抑素C：幼儿肾功能更可靠的生物标志物？一项纵向队列研究。
Cystatin C: A more reliable biomarker of renal function in young infants? A longitudinal cohort study.
作者信息
Kandasamy Yogavijayan, Rudd Donna
机构信息
Department of Neonatology, The Townsville Hospital, Douglas, Qld, Australia.
Mothers and Babies Research Centre, Hunter Medical Research Institute, HMRI, The University of Newcastle, Newcastle, NSW, Australia.
出版信息
Acta Paediatr. 2021 Apr;110(4):1341-1345. doi: 10.1111/apa.15538. Epub 2020 Sep 1.
AIM
We carried out a longitudinal cohort study to measure serial CysC (Cystatin C) in a cohort of neonates born preterm until the age of 2 years. We hypothesised that CysC levels are independent of body weight and would not vary with gestational age.
METHODS
This prospective cohort study was conducted from August 2014 until October 2016, and follow-up was completed in October 2018. Preterm infants at less than 28 weeks of gestation (extremely preterm infants) were recruited and followed up until the age of 24 months. Blood samples for measurement of CysC were collected at regular intervals.
RESULTS
We recruited 58 preterm neonates with mean gestation was 26.2 (1.5) weeks, and a mean birth weight was 917 (140) g. One-way analysis of variance (ANOVA) did not show any significant difference in CysC levels between 28, 32 and 37 weeks' gestation (P = .09) despite a significant increase in body weight (P < .001). The mean CysC level was higher in the neonatal period and subsequently plateaued by 24 months.
CONCLUSION
Serum CysC level is independent of body weight and not influenced by postnatal age nor by gender.
目的
我们开展了一项纵向队列研究，以测量一组早产新生儿直至2岁时的连续胱抑素C（CysC）水平。我们假设CysC水平与体重无关，且不会随胎龄变化。
方法
这项前瞻性队列研究于2014年8月至2016年10月进行，随访于2018年10月完成。招募妊娠小于28周的早产儿（极早产儿）并随访至24个月龄。定期采集用于测量CysC的血样。
结果
我们招募了58名早产新生儿，平均胎龄为26.2（1.5）周，平均出生体重为917（140）克。尽管体重显著增加（P <.001），但单因素方差分析（ANOVA）未显示28、32和37周胎龄之间的CysC水平有任何显著差异（P =.09）。新生儿期的平均CysC水平较高，随后在24个月时趋于平稳。
结论
血清CysC水平与体重无关，不受出生后年龄和性别的影响。
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