Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Ann Neurol. 2020 Nov;88(5):1034-1042. doi: 10.1002/ana.25877. Epub 2020 Sep 9.
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034-1042.
在多发性硬化症（MS）中，磁共振成像上可以通过其顺磁性边缘识别出一部分慢性活跃的白质病变，越来越多的证据支持它们与临床疾病严重程度的关联。我们研究了它们在鉴别诊断中的潜在作用，在一个由 438 名患有不同神经疾病（MS、其他炎症性、感染性和非炎症性疾病）的国际多中心临床研究样本中进行了筛选。顺磁性边缘病变在其他神经疾病中很少见（MS 中为 52%，非-MS 病例中为 7%），在区分 MS 和非-MS 方面具有很高的特异性（93%）。未来的前瞻性多中心研究应该验证它们作为诊断生物标志物的作用。ANN NEUROL 2020；88：1034-1042。
