• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

清酒乳杆菌抑制胶原诱导性关节炎，并调节辅助性 T 细胞 17 和调节性 B 细胞的分化。

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells.

机构信息

Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Laboratory of Immune Network, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

出版信息

J Transl Med. 2020 Aug 15;18(1):317. doi: 10.1186/s12967-020-02477-8.

DOI:10.1186/s12967-020-02477-8
PMID:32799896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7429687/
Abstract

BACKGROUND

To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

METHODS

We evaluated whether L. sakei reduced the severity of collagen-induced arthritis (CIA) and modulated interleukin (IL)-17 and IL-10 levels, as well as whether it affected the differentiation of CD4 T cells and regulatory B cells. We evaluated osteoclastogenesis after culturing bone marrow-derived mononuclear cells with L. sakei.

RESULTS

The differentiation of T helper 17 cells and the serum level of IL-17 were suppressed by L. sakei in both human peripheral blood mononuclear cells and mouse splenocytes. The serum level of IL-10 was significantly increased in the L. sakei-treated group, whereas the regulatory T cell population was unchanged. The population of regulatory B cells significantly increased the in L. sakei-treated group. Oral administration of L. sakei reduced the arthritis incidence and score in mice with CIA. Finally, osteoclastogenesis and the mRNA levels of osteoclast-related genes were suppressed in the L. sakei-treated group.

CONCLUSION

L. sakei exerted an anti-inflammatory effect in an animal model of RA, regulated Th17 and regulatory B cell differentiation, and suppressed osteoclastogenesis. Our findings suggest that L. sakei has therapeutic potential for RA.

摘要

背景

评估清酒乳杆菌在类风湿关节炎（RA）小鼠模型和人免疫细胞中的免疫调节作用。

方法

我们评估了清酒乳杆菌是否能减轻胶原诱导性关节炎（CIA）的严重程度，并调节白细胞介素（IL）-17 和 IL-10 水平，以及它是否影响 CD4 T 细胞和调节性 B 细胞的分化。我们评估了培养骨髓来源的单核细胞后清酒乳杆菌对破骨细胞生成的影响。

结果

清酒乳杆菌在人外周血单核细胞和小鼠脾细胞中均抑制辅助性 T 细胞 17 细胞的分化和血清中 IL-17 的水平。清酒乳杆菌治疗组血清中 IL-10 水平显著升高，而调节性 T 细胞群体不变。清酒乳杆菌治疗组调节性 B 细胞群体显著增加。口服清酒乳杆菌可降低 CIA 小鼠的关节炎发生率和评分。最后，清酒乳杆菌治疗组破骨细胞生成和破骨细胞相关基因的 mRNA 水平受到抑制。

结论

清酒乳杆菌在 RA 动物模型中发挥抗炎作用，调节 Th17 和调节性 B 细胞分化，并抑制破骨细胞生成。我们的研究结果表明，清酒乳杆菌具有治疗 RA 的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/97ea3df75ca0/12967_2020_2477_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/5eea0186fd20/12967_2020_2477_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/7991c340623a/12967_2020_2477_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/ee2bba078183/12967_2020_2477_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/ff1e1abf7311/12967_2020_2477_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/97ea3df75ca0/12967_2020_2477_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/5eea0186fd20/12967_2020_2477_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/7991c340623a/12967_2020_2477_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/ee2bba078183/12967_2020_2477_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/ff1e1abf7311/12967_2020_2477_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b00/7429687/97ea3df75ca0/12967_2020_2477_Fig5_HTML.jpg

相似文献

1
Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells.清酒乳杆菌抑制胶原诱导性关节炎，并调节辅助性 T 细胞 17 和调节性 B 细胞的分化。
J Transl Med. 2020 Aug 15;18(1):317. doi: 10.1186/s12967-020-02477-8.
2
WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice.WIKIM30 通过诱导调节性 T 细胞和改变小鼠肠道微生物群结构来改善特应性皮炎样皮肤损伤。
Front Immunol. 2018 Aug 14;9:1905. doi: 10.3389/fimmu.2018.01905. eCollection 2018.
3
Moxibustion regulates T-regulatory/T-helper 17 cell balance by modulating the microRNA-221/suppressor of cytokine signaling 3 axis in a mouse model of rheumatoid arthritis.艾灸通过调节 miRNA-221/细胞因子信号转导抑制因子 3 轴调节类风湿关节炎小鼠模型中的 T 调节/T 辅助 17 细胞平衡。
J Integr Med. 2022 Sep;20(5):453-462. doi: 10.1016/j.joim.2022.06.002. Epub 2022 Jun 10.
4
Lactobacillus salivarius Isolated from Patients with Rheumatoid Arthritis Suppresses Collagen-Induced Arthritis and Increases Treg Frequency in Mice.从类风湿性关节炎患者中分离出的唾液乳杆菌可抑制小鼠胶原诱导的关节炎并增加调节性T细胞频率。
J Interferon Cytokine Res. 2016 Dec;36(12):706-712. doi: 10.1089/jir.2016.0057. Epub 2016 Nov 15.
5
IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.白细胞介素-18 结合蛋白抑制白细胞介素-17 诱导的破骨细胞生成，并纠正类风湿关节炎中 17 型辅助 T 细胞/调节性 T 细胞失衡。
J Transl Med. 2021 Sep 16;19(1):392. doi: 10.1186/s12967-021-03071-2.
6
Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.从黑豆种皮中提取的花青素通过抑制NF-κB，抑制Th17细胞的发育及其促炎细胞因子的合成，从而预防自身免疫性关节炎。
PLoS One. 2015 Nov 6;10(11):e0138201. doi: 10.1371/journal.pone.0138201. eCollection 2015.
7
Gene associated with retinoid-interferon-induced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and treg cells.与维甲酸-干扰素诱导的死亡率 19 相关的基因通过调节 Th17 和 Treg 细胞来减轻小鼠自身免疫性关节炎。
Arthritis Rheumatol. 2014 Mar;66(3):569-78. doi: 10.1002/art.38267.
8
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.在已建立的小鼠II型胶原诱导性关节炎中，通过全身性白细胞介素-4治疗预防软骨和骨破坏。
Arthritis Res. 1999;1(1):81-91. doi: 10.1186/ar14. Epub 1999 Oct 26.
9
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.IL-27 的体内作用：胶原诱导性关节炎中 Th17 和 Treg 细胞的相互调节。
Exp Mol Med. 2013 Oct 4;45(10):e46. doi: 10.1038/emm.2013.89.
10
Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis.通过下调 Th17 分化和破骨细胞生成来缓解关节炎的 gp130 靶向和 TNF 靶向小分子的联合作用。
Biochem Biophys Res Commun. 2020 Feb 19;522(4):1030-1036. doi: 10.1016/j.bbrc.2019.11.183. Epub 2019 Dec 6.

引用本文的文献

1
Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis.益生菌衍生的细胞外囊泡：类风湿性关节炎后生元的下一个突破。
Front Immunol. 2025 Aug 7;16:1620185. doi: 10.3389/fimmu.2025.1620185. eCollection 2025.
2
Efficacy and safety of Latilactobacillus sakei LB-P12 in patients with knee osteoarthritis: an exploratory randomized, double-blind, placebo-controlled clinical trial.清酒乳杆菌LB-P12治疗膝骨关节炎患者的疗效和安全性：一项探索性随机双盲安慰剂对照临床试验
Sci Rep. 2025 Jul 17;15(1):25980. doi: 10.1038/s41598-025-11250-0.
3
Anti-Inflammatory Effect and Gut Health of Levilactobacillus brevis Strains in Macrophage and Intestinal Cells.

本文引用的文献

1
S1 Improves Colitis Induced by 2,4,6-Trinitrobenzene Sulfonic Acid by the Inhibition of NF-κB Signaling in Mice.S1 通过抑制 NF-κB 信号通路改善 2,4,6-三硝基苯磺酸诱导的结肠炎。
J Microbiol Biotechnol. 2020 Jan 28;30(1):71-78. doi: 10.4014/jmb.1907.07050.
2
The role of microbiome in rheumatoid arthritis treatment.微生物群落在类风湿性关节炎治疗中的作用。
Ther Adv Musculoskelet Dis. 2019 Jul 30;11:1759720X19844632. doi: 10.1177/1759720X19844632. eCollection 2019.
3
Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model.
短乳杆菌菌株在巨噬细胞和肠道细胞中的抗炎作用及肠道健康
Probiotics Antimicrob Proteins. 2025 Jun 10. doi: 10.1007/s12602-025-10621-3.
4
Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development.肠道-关节轴：双歧杆菌细胞壁脂蛋白对关节炎发展的影响。
Nutrients. 2023 Nov 21;15(23):4861. doi: 10.3390/nu15234861.
5
Paraprobiotics: definition, manufacturing methods, and functionality.副益生菌：定义、生产方法及功能
Food Sci Biotechnol. 2023 Jul 17;32(14):1981-1991. doi: 10.1007/s10068-023-01378-y. eCollection 2023 Dec.
6
Effect of OK67 in Reducing Body and Visceral Fat in Lifestyle-Modified Overweight Individuals: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.生活方式调整超重个体中 OK67 降低体脂和内脏脂肪的效果：一项为期 12 周、随机、双盲、安慰剂对照的临床试验。
Nutrients. 2023 Jul 7;15(13):3074. doi: 10.3390/nu15133074.
7
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis.肠道微生物群对骨重塑的调节作用：骨质疏松症的一种新疗法。
Bone Res. 2023 Jun 9;11(1):31. doi: 10.1038/s41413-023-00264-x.
8
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation.小异二聚体伴侣相互作用亮氨酸拉链蛋白 (SMILE) 通过 AMPK 信号通路和 B 细胞激活的调节改善自身免疫性关节炎。
Cell Commun Signal. 2023 May 4;21(1):98. doi: 10.1186/s12964-023-01054-y.
9
A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-B pathway.一种新型 IRAK4/PIM1 抑制剂通过阻断 TLR/MYD88 介导的 NF-κB 通路改善类风湿性关节炎和淋巴系统恶性肿瘤。
Acta Pharm Sin B. 2023 Mar;13(3):1093-1109. doi: 10.1016/j.apsb.2022.12.001. Epub 2022 Dec 5.
10
-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis.介导胆汁酸代谢通过肠道-关节轴预防类风湿关节炎。
Nutrients. 2023 Jan 4;15(2):255. doi: 10.3390/nu15020255.
植物乳杆菌 CJLS03 对高脂肪饮食诱导肥胖模型肥胖相关生物标志物的改善作用。
Sci Rep. 2019 May 2;9(1):6821. doi: 10.1038/s41598-019-43092-y.
4
PC1 has the Capacity to Attenuate Joint Inflammation in Collagen-Induced Arthritis in DBA/1 Mice.PC1 具有减轻胶原诱导性关节炎 DBA/1 小鼠关节炎症的能力。
Nutrients. 2019 Apr 5;11(4):785. doi: 10.3390/nu11040785.
5
IL-17 in Rheumatoid Arthritis and Precision Medicine: From Synovitis Expression to Circulating Bioactive Levels.类风湿关节炎中的白细胞介素-17与精准医学：从滑膜炎表达至循环生物活性水平
Front Med (Lausanne). 2019 Jan 14;5:364. doi: 10.3389/fmed.2018.00364. eCollection 2018.
6
Diagnosis and Management of Rheumatoid Arthritis: A Review.类风湿关节炎的诊断与治疗：综述。
JAMA. 2018 Oct 2;320(13):1360-1372. doi: 10.1001/jama.2018.13103.
7
Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis.与肠道对话：口腔-肠道微生物轴及其在类风湿关节炎发病机制中的免疫调节作用。
FEMS Microbiol Rev. 2019 Jan 1;43(1):1-18. doi: 10.1093/femsre/fuy035.
8
WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice.WIKIM30 通过诱导调节性 T 细胞和改变小鼠肠道微生物群结构来改善特应性皮炎样皮肤损伤。
Front Immunol. 2018 Aug 14;9:1905. doi: 10.3389/fimmu.2018.01905. eCollection 2018.
9
Experimental animal models for rheumatoid arthritis.类风湿关节炎的实验动物模型。
Immunopharmacol Immunotoxicol. 2018 Jun;40(3):193-200. doi: 10.1080/08923973.2018.1434793. Epub 2018 Feb 12.
10
Rheumatoid arthritis.类风湿关节炎。
Nat Rev Dis Primers. 2018 Feb 8;4:18001. doi: 10.1038/nrdp.2018.1.