Lyu Zhengtian, Hu Yongfei, Guo Yuming, Liu Dan
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Bone Res. 2023 Jun 9;11(1):31. doi: 10.1038/s41413-023-00264-x.
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, including probiotics or antibiotics, have been found to affect bone remodeling. This review provides a comprehensive summary of recent research on the role of GM in regulating bone remodeling and seeks to elucidate the regulatory mechanism from various perspectives, such as the interaction with the immune system, interplay with estrogen or parathyroid hormone (PTH), the impact of GM metabolites, and the effect of extracellular vesicles (EVs). Moreover, this review explores the potential of probiotics as a therapeutic approach for OP. The insights presented may contribute to the development of innovative GM-targeted therapies for OP.
肠道微生物群（GM）在维持宿主的整体健康和福祉方面起着至关重要的作用。最近的研究表明，GM可能会显著影响骨代谢和退行性骨骼疾病，如骨质疏松症（OP）。已发现针对GM修饰的干预措施，包括益生菌或抗生素，会影响骨重塑。本综述全面总结了GM在调节骨重塑中作用的最新研究，并试图从多个角度阐明其调节机制，如与免疫系统的相互作用、与雌激素或甲状旁腺激素（PTH）的相互作用、GM代谢产物的影响以及细胞外囊泡（EVs）的作用。此外，本综述探讨了益生菌作为OP治疗方法的潜力。所提出的见解可能有助于开发针对GM的OP创新疗法。
