Waqas Muhammad, Us-Salam Iram, Bibi Zainab, Wang Yunfeng, Li He, Zhu Zhongshou, He Shuangba
Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan.
Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China.
Neural Plast. 2020 Aug 1;2020:8829660. doi: 10.1155/2020/8829660. eCollection 2020.
The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent. Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. In this review, we specifically discuss the potential of different kinds of stem cells that hold the potential to restore sensorineural hearing loss in mammals and comprehensively explain the current therapeutic applications of stem cells in both the human and mouse inner ear to regenerate/replace the lost hair cells and spiral ganglion neurons.
位于耳蜗感觉上皮中的毛细胞是负责感知环境中诱发的机械声波的基本感觉结构。这些感觉结构的严重损伤可能导致永久性听力损失。目前恢复听力功能的策略包括使用助听器或人工耳蜗，它们可以在一定程度上恢复聋人患者的听力。因此，人们非常关注开发再生疗法，以再生/替代丢失的毛细胞，治疗受损的耳蜗感觉上皮。干细胞疗法是一种很有前景的方法，可从内源性和外源性干细胞库中发育出功能性毛细胞和神经元细胞，以恢复听力损失。在这篇综述中，我们具体讨论了不同种类干细胞在恢复哺乳动物感音神经性听力损失方面的潜力，并全面解释了干细胞目前在人类和小鼠内耳中的治疗应用，以再生/替代丢失的毛细胞和螺旋神经节神经元。
